Hematologic disease

MeSH | D006402

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Hematologic diseases are disorders which primarily affect the blood.

## Classification of hematologic diseases

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* Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
* Sickle-cell disease
* Thalassemia
* Methemoglobinemia
* Anemias (lack of red blood cells or hemoglobin)
* Iron deficiency anemia
* Megaloblastic anemia
* Vitamin B12 deficiency
* Pernicious anemia
* Folate deficiency
* Hemolytic anemias (destruction of red blood cells)
* Genetic disorders of RBC membrane
* Hereditary spherocytosis
* Hereditary elliptocytosis
* Genetic disorders of RBC metabolism
* Glucose-6-phosphate dehydrogenase deficiency (G6PD)
* Pyruvate kinase deficiency
* Immune mediated hemolytic anaemia (direct Coombs test is positive)
* Autoimmune hemolytic anemia
* Warm antibody autoimmune hemolytic anemia
* Idiopathic
* Systemic lupus erythematosus (SLE)
* Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
* Cold antibody autoimmune hemolytic anemia
* Idiopathic cold hemagglutinin syndrome
* Infectious mononucleosis
* Paroxysmal cold hemoglobinuria (rare)
* Alloimmune hemolytic anemia
* Hemolytic disease of the newborn (HDN)
* Rh disease (Rh D)
* ABO hemolytic disease of the newborn
* Anti-Kell hemolytic disease of the newborn
* Rhesus c hemolytic disease of the newborn
* Rhesus E hemolytic disease of the newborn
* Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
* Drug induced immune mediated hemolytic anaemia
* Penicillin (high dose)
* Methyldopa
* Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
* Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
* Direct physical damage to RBCs
* Microangiopathic hemolytic anemia
* Secondary to artificial heart valve(s)
* Aplastic anemia
* Fanconi anemia
* Diamond-Blackfan anemia
* Acquired pure red cell aplasia
* Decreased numbers of cells
* Myelodysplastic syndrome
* Myelofibrosis
* Neutropenia (decrease in the number of neutrophils)
* Agranulocytosis
* Glanzmann's thrombasthenia
* Thrombocytopenia (decrease in the number of platelets)
* Idiopathic thrombocytopenic purpura (ITP)
* Thrombotic thrombocytopenic purpura (TTP)
* Heparin-induced thrombocytopenia (HIT)
* Myeloproliferative disorders (Increased numbers of cells)
* Polycythemia vera (increase in the number of cells in general)
* Leukocytosis (increase in the number of white blood cells)
* Thrombocytosis (increase in the number of platelets)
* Myeloproliferative disorder
* Hematological malignancies
* Lymphomas
* Hodgkin's disease
* Non-Hodgkin's lymphoma{includes the next eight entries}
* Burkitt's lymphoma
* Anaplastic large cell lymphoma
* Splenic marginal zone lymphoma
* Hepatosplenic T-cell lymphoma
* Angioimmunoblastic T-cell lymphoma (AILT)
* Myelomas
* Multiple myeloma
* Waldenström macroglobulinemia
* Plasmacytoma
* Leukemias
* Acute lymphocytic leukemia (ALL)
* Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
* Acute myelogenous leukemia (AML)
* Chronic myelogenous leukemia (CML)
* T-cell prolymphocytic leukemia (T-PLL)
* B-cell prolymphocytic leukemia (B-PLL)
* Chronic neutrophilic leukemia (CNL)
* Hairy cell leukemia (HCL)
* T-cell large granular lymphocyte leukemia (T-LGL)
* Aggressive NK-cell leukemia
* Coagulopathies (disorders of bleeding and coagulation)
* Thrombocytosis
* Recurrent thrombosis
* Disseminated intravascular coagulation
* Disorders of clotting proteins
* Hemophilia
* Hemophilia A
* Hemophilia B (also known as Christmas disease)
* Hemophilia C
* Von Willebrand disease
* Disseminated intravascular coagulation
* Protein S deficiency
* Antiphospholipid syndrome
* Disorders of platelets
* Thrombocytopenia
* Glanzmann's thrombasthenia
* Wiskott-Aldrich syndrome
* Miscellaneous
* Haemochromatosis
* Asplenia
* Hypersplenism
* Gauchers disease
* Monoclonal gammopathy of undetermined significance
* Hematological changes secondary to non-hematological disorders
* Anemia of chronic disease
* Infectious mononucleosis
* AIDS
* Malaria
* Leishmaniasis

## External links

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* http://www.hematologic.niddk.nih.gov/info/index.htm
* Myeloproliferative Disorders (MPD) Foundation and Research Alliance

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