Henoch-Schönlein purpura causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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The common causes of Henoch-Schönlein purpura (HSP) are infections, medications, hypersensitivity, vaccinations, genetics etc.

## Causes

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* The causes of the HSP is as follows:[1][2][3][4][5][6]
* The exact cause of HSP is not clear.

* Common causes
* Infections-
* Medications
* Hypersensitivity
* Vaccinations\- certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.
* Rare causes
* Genetics\- very rarely HSP can occur in twins and within the family
* Other triggers Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
* In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
* Allergic reaction to foods may cause HSP.
* Very rarely HSP can occur in twins and within the family.

## References

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1. ↑ Davin JC, Coppo R (October 2014). "Henoch-Schönlein purpura nephritis in children". Nat Rev Nephrol. 10 (10): 563–73. doi:10.1038/nrneph.2014.126. PMID 25072122.
2. ↑ Micheletti RG, Werth VP (2015). "Small vessel vasculitis of the skin". Rheum. Dis. Clin. North Am. 41 (1): 21–32, vii. doi:10.1016/j.rdc.2014.09.006. PMID 25399937.
3. ↑ Zhdanova LV, Patrushev LI, Dolgikh VV, Bimbaev AB, Khoĭkova O (2014). "[The contribution of genes polymorphism of thrombophilia in clinical variability of hemorrhagic vasculitis]". Vestn. Akad. Med. Nauk SSSR (in Russian) (3–4): 61–4. PMID 25306598. Vancouver style error: initials (help)CS1 maint: Unrecognized language (link)
4. ↑ Rigante D, Castellazzi L, Bosco A, Esposito S (August 2013). "Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?". Autoimmun Rev. 12 (10): 1016–21. doi:10.1016/j.autrev.2013.04.003. PMID 23684700.
5. ↑ Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B (July 2015). "IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects". Autoimmun Rev. 14 (7): 579–85. doi:10.1016/j.autrev.2015.02.003. PMID 25688001.
6. ↑ Pillebout E, Niaudet P (March 2008). "[Henoch-Schönlein purpura]". Rev Prat (in French). 58 (5): 507–11. PMID 18524107.CS1 maint: Unrecognized language (link)

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