Henoch-Schönlein purpura laboratory findings

Henoch-Schönlein purpura Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Henoch-Schönlein purpura from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Henoch-Schönlein purpura laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Henoch-Schönlein purpura laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Henoch-Schönlein purpura laboratory findings

CDC on Henoch-Schönlein purpura laboratory findings

Henoch-Schönlein purpura laboratory findings in the news

Blogs on Henoch-Schönlein purpura laboratory findings

Directions to Hospitals Treating Henoch-Schönlein purpura

Risk calculators and risk factors for Henoch-Schönlein purpura laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

[edit | edit source]

There is no specific diagnostic test available for HSP. Platelet count, coagulation studies such as PT, aPTT, and BT are done to rule out other diseases like coagulopathies. They are usually normal. Urinalysis is done to check for any blood in the urine or proteinuria for renal involvement. Serum IgA levels are elevated in the majority of patients with HSP, and in patients with renal involvement higher IgA levels are detected.

## Laboratory findings

[edit | edit source]

* Laboratory findings of HSP:[1][2][3][4]
* There is no specific diagnostic test available for HSP.
* Platelet count, coagulation studies such as PT, aPTT, and BT is done to rule out other diseases like coagulopathies. They are usually normal.
* Urinalysis, is done to check for any blood in the urine or proteinuria for renal involvement.
* Serum IgA levels are elevated in the majority of patients with HSP, and in patients with renal involvement higher IgA levels are detected.
* The routine blood tests CBC (complete blood count), metabolic profile, urinalysis are usually inconclusive.
* Patients with occult GI bleeding may have anemia.
* Since HSP is a type-III hypersensitivity reaction complements are consumed by the immune complexes eventually leading to hypocomplementemia (decreased C3 and C4).
* Leukocytosis and elevated acute phase reactants are noted in patients with HSP secondary to bacterial infections.

## References

[edit | edit source]

1. ↑ Calviño MC, Llorca J, García-Porrúa C, Fernández-Iglesias JL, Rodriguez-Ledo P, González-Gay MA (September 2001). "Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study". Medicine (Baltimore). 80 (5): 279–90. PMID 11552081.
2. ↑ Trygstad CW, Stiehm ER (June 1971). "Elevated serum IgA globulin in anaphylactoid purpura". Pediatrics. 47 (6): 1023–8. PMID 5003905.
3. ↑ Davin JC, Ten Berge IJ, Weening JJ (March 2001). "What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?". Kidney Int. 59 (3): 823–34. doi:10.1046/j.1523-1755.2001.059003823.x. PMID 11231337.
4. ↑ Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X (May 2012). "Henoch-Schönlein purpura with hypocomplementemia". Pediatr. Nephrol. 27 (5): 801–6. doi:10.1007/s00467-011-2070-z. PMID 22271365.

Template:WH Template:WS