Henoch-Schönlein purpura other diagnostic studies

Henoch-Schönlein purpura Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Henoch-Schönlein purpura from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Henoch-Schönlein purpura other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Henoch-Schönlein purpura other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Henoch-Schönlein purpura other diagnostic studies

CDC on Henoch-Schönlein purpura other diagnostic studies

Henoch-Schönlein purpura other diagnostic studies in the news

Blogs on Henoch-Schönlein purpura other diagnostic studies

Directions to Hospitals Treating Henoch-Schönlein purpura

Risk calculators and risk factors for Henoch-Schönlein purpura other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

[edit | edit source]

Henoch-Schönlein purpura is diagnosed using a biopsy of the skin and kidney.

## Other Diagnostic Studies

[edit | edit source]

Biopsy[1][2][3]

* Indications
* No rash
* Abnormal renal function tests

Skin biopsy

* Light Microscopy
* IgA deposition in postcapillary venules with IgA deposition and leukocytoclastic vasculitis in is a pathognomonic microscopic feature of Henoch-Schönlein Purpura.
* Skin lesions less than 24 hrs are preferred as the chronic lesion lack the immunoglobulin isotypes essential for the diagnosis of HSP.
* A biopsy from a different skin site is taken for the immunofluorescent studies to confirm the diagnosis.

Renal biopsy

* IgA deposition in the mesangium on immunofluorescence microscopy should be differentiated from the IgA nephropathy.
* Light microscopic features range from isolated mesangial proliferation to severe crescentic glomerulonephritis.

## References

[edit | edit source]

1. ↑ Jennette JC, Falk RJ (November 1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512–23. doi:10.1056/NEJM199711203372106. PMID 9366584.
2. ↑ Chen JY, Mao JH (February 2015). "Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management". World J Pediatr. 11 (1): 29–34. doi:10.1007/s12519-014-0534-5. PMID 25557596.
3. ↑ Kawasaki Y, Ono A, Ohara S, Suzuki Y, Suyama K, Suzuki J, Hosoya M (2013). "Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment". Fukushima J Med Sci. 59 (1): 15–26. PMID 23842510.

Template:WH Template:WS