Hyperthermia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Kiran Singh, M.D. [2]

## Overview

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Life threatning causes of hyperthermia include diabetic ketoacidosis, heat stroke, malignant hyperthermia, and septic shock. Other common causes of hyperthermia are amphetamine, cocaine, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors.

## Causes

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### Life Threatening Causes

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* Diabetic ketoacidosis
* Heat stroke
* Malignant hyperthermia
* Neonatal sepsis
* Septic shock

### Common Causes

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* Amphetamine
* Cocaine
* Monoamine oxidase inhibitors
* Selective serotonin reuptake inhibitors
* Tricyclic antidepressants

### Causes by Organ System

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Cardiovascular | Dressler syndrome,Kawasaki disease

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Chemical/Poisoning | Methyl bromide, saponin, acetylsalicylic acid, amphetamine poisoning, anticholinergic poisoning, antipsychotic poisoning, benzphetamine hydrochloride, boric acid, cathinone poisoning, cobra poisoning, cocaine poisoning, cyclic antidepressant poisoning, dinitrocresol, dinitrophenol, funnel web spider poisoning, hexachlorobenzene, lysergic acid diethylamide, MAO inhibitor poisoning, metaldehyde, mustard tree poisoning, nitrogen dioxide, phencyclidine poisoning, salicylate poisoning, strychnine, toxaphene, toxic mushrooms
Dental | No underlying causes
Dermatologic | Cellulitis, hidradenitis suppurativa, hydroa vacciniforme, impetigo herpetiformis, scarlet fever, thrombotic thrombocytopenic purpura,
Drug Side Effect | 5-azacytidine, abacavir, amphetamines, anticholinergics, asparaginase, benztropine mesylate, bleomycin, bretylium tosylate, cocaine, cyclic antidepressant poisoning, dabrafenib, didrex, dimercaprol, dinoprostone, diphtheria-pertussis-tetanus vaccine, elotuzumab, elspar, eribulin mesylate, ganciclovir, glycopyrrolate, imatinib mesylate, ioxilan,LSD, MDMA, methscopolamine bromide, mepenzolate, micafungin, MMR vaccine, monoamine oxidase inhibitors, muscarinic antagonists, oxaliplatin, para-amino salicylic acid, PCP, penicillaminepropantheline bromide, psychostimulant drugs, psychotropic medications, pyrazinamide, selective serotonin reuptake inhibitors, Serotonin syndrome, succimer, Talimogene laherparepvec, tricyclic antidepressants, valganciclovir
Ear Nose Throat | Vincent angina
Endocrine | De Quervain's thyroiditis ,diabetic ketoacidosis,pheochromocytoma,thyroid storm
Environmental | Humidity
Gastroenterologic | Cholecystitis,gallbladder empyema,yellow fever
Genetic | Crisponi syndrome,pseudodiastrophic dysplasia,Stuve-Wiedemann dysplasia
Hematologic | Acute infantile hemorrhagic oedema, blood transfusion and complications, Burkitt lymphoma, lymphangitis, lymphoma, thrombotic thrombocytopenic purpura, tropical pulmonary eosinophilia
Iatrogenic | No underlying causes
Infectious Disease | Acute disseminated encephalomyelitis, anthrax, babesiosis, bartonellosis, Bornholm disease, brain abscess, Brazilian purpuric fever, campylobacter jejuni, caspofungin, cellulitis, Chagas disease, Colorado tick fever, common cold, cystitis, infective, dengue, ehrlichia ewingii, encephalitis, epiglottitis, erysipelas,erysipeloid of rosenbach, gallbladder empyema, hand-foot-mouth syndrome, heartland virus, herpes virus 6, human monocytotropic ehrlichiosis, influenza, Kunjin virus, lassa fever, lymphangitis, malaria, measles, mediastinitis, meningitis, Murray Valley encephalitis virus, Nanukayami, Oklahoma tick fever, neonatal sepsis, orbital cellulitis, PCP, pelvic inflammatory disease, pericoronitis, rabies, rickettsia prowazekii, scarlet fever, schistosoma haematobium, secondary syphilis, Sennetsu fever, sepsis, septic shock, smallpox, staphylococcal toxic shock syndrome, subacute sclerosing leukoencephalitis, tanapox virus disease, tetanus, toxic shock syndrome, trench fever, trichinella spiralis, tropical pulmonary eosinophilia, typhoid fever, vincent angina, viral haemorrhagic fever, yellow fever, yersinia pestisZika virus disease,
Musculoskeletal/Orthopedic | Malignant hyperpyrexia
Neurologic | Acute disseminated encephalomyelitis, Aicardi-Goutieres syndrome, autonomic neuropathy, brain abscess, cerebral hemorrhage, familial hemiplegic migraine, meningitis, status epilepticus, subacute sclerosing leukoencephalitis
Nutritional/Metabolic | Calcitriol, dehydration, Gtp cyclohydrolase deficiency, heat cramps, hypernatremia, hyponatremia, Ornithine transcarbamylase deficiency, streptokinase
Obstetric/Gynecologic | Pelvic inflammatory disease, puerperal pyrexia
Oncologic | Burkitt lymphoma, leukemia, lymphoma, mastocytosis, nephroblastoma
Ophthalmologic | Orbital cellulitis
Overdose/Toxicity | Autumn crocus, Cocaine overdose, Ecstasy abuse, MDMA
Psychiatric | Neuroleptic malignant syndrome
Pulmonary | Bronchiolitis obliterans organizing pneumonia, common cold, extrinsic allergic alveolitis, Idiopathic pulmonary haemosiderosis, lymphocytic interstitial pneumonia, mediastinitis, PCP, severe acute respiratory syndrome,
Renal/Electrolyte | Nephroblastoma, renal infarction
Rheumatology/Immunology/Allergy | Acute disseminated encephalomyelitis, Aicardi-Goutieres syndrome, Interferon beta, Interferon gamma, Interleukin 2, Kawasaki disease, macrophage activation syndrome, thrombotic thrombocytopenic purpura, urate crystal arthropathy
Sexual | No underlying causes
Trauma | Crush injury
Urologic | Cystitis infective, malakoplakia
Miscellaneous | Pyrexia of unknown origin

### Causes in Alphabetical Order

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## References

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