Hypertrophic cardiomyopathy in cats

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Editors-In-Chief: C. Michael Gibson, M.S., M.D. [1], Cafer Zorkun, M.D. [2], Caitlin J. Harrigan [3], Martin S. Maron, M.D., and Barry J. Maron, M.D.

## Feline hypertrophic cardiomyopathy

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Feline hypertrophic cardiomyopathy is the most common heart disease in cats; the disease process and genetics are believed to be similar to the disease in humans.[1] The first genetic mutation (in cardiac myosin binding protein C) responsible for feline hypertrophic cardiomyopathy was discovered in 2005 in Maine Coon cats.[2] A test for this mutation is available.[3] About one third of Maine Coon cats tested for the mutation have been shown to be either heterozygous and homozygous for the mutation, although many of these cats have no clinical signs of the disease. Some Maine Coon cats with clinical evidence of hypertrophic cardiomyopathy test negative for this mutation, strongly suggesting that a second mutation exists in the breed. The cardiac myosin binding protein C mutation has not been found in any other breed of cat with HCM.

## References

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1. ↑ Kittleson M, Meurs K, Munro M, Kittleson J, Liu S, Pion P, Towbin J (1999). "Familial hypertrophic cardiomyopathy in maine coon cats: an animal model of human disease". Circulation. 99 (24): 3172–80. PMID 10377082.CS1 maint: Multiple names: authors list (link)
2. ↑ Meurs K, Sanchez X, David R, Bowles N, Towbin J, Reiser P, Kittleson J, Munro M, Dryburgh K, Macdonald K, Kittleson M (2005). "A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy". Hum Mol Genet. 14 (23): 3587–93. PMID 16236761.CS1 maint: Multiple names: authors list (link)
3. ↑ Veterinary Cardiac Genetics Laboratory of the College of Veterinary Medicine

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