Intercalated disc

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview[edit | edit source]

An intercalated disc is an undulating double membrane separating adjacent cells in cardiac muscle fibers. Intercalated discs support synchronized contraction of cardiac tissue. They can easily be visualized by a longitudinal section of the tissue.

Three types of membrane junctions exist within an intercalated disc—fascia adherens, macula adherens, and gap junctions.

* Fascia adherens are anchoring sites for actin, and connects to the closest sarcomere.

* Macula adherens stop separation during contraction by binding intermediate filaments joining the cells together also called a desmosome.

* Gap junctions allow action potentials to spread between cardiac cells by permitting the passage of ions between cells, producing depolarization of the heart muscle.

When observing cardiac tissue through a microscope, intercalated discs are an identifying feature of cardiac muscle.

## See also[edit | edit source]

* Gap junction
* Cardiac muscle

## External links[edit | edit source]

* Template:EMedicineDictionary
* Histology at BU "Ultrastructure of the Cell: cardiac muscle, intercalated disk "

* v
* t
* e

Muscle tissue

Smooth
muscle|

* Calmodulin
* Vascular smooth muscle

Striated
muscle|

| Skeletal
muscle|

| Costamere/
DAPC|

| Membrane/
extracellular|

| DAP:|

* Sarcoglycan
* SGCA
* SGCB
* SGCD
* SGCE
* SGCG
* SGCZ
* Dystroglycan

|

* Sarcospan
* Laminin, alpha 2

Intracellular|

* Dystrophin
* Dystrobrevin
* A
* B
* Syntrophin
* A
* B1
* B2
* G1
* G2
* Syncoilin
* Dysbindin
* Synemin/desmuslin

related:|

* NOS1
* Caveolin 3

Sarcomere/
(a, i, and h bands;
z and m lines)|

* Myofilament
* thin filament/actin
* thick filament/myosin
* elastic filament/titin
* nebulin

* Tropomyosin

* Troponin
* T
* C
* I

Connective tissue|

* Epimysium
* Fascicle
* Perimysium
* Endomysium
* Connective tissue in skeletal muscle

General|

* Neuromuscular junction
* Motor unit
* Muscle spindle
* Excitation–contraction coupling
* Sliding filament mechanism

Cardiac
muscle|

* Myocardium
* Intercalated disc
* Nebulette

Both|

| Fiber|

* Muscle fiber
* intrafusal
* extrafusal
* Myofibril
* Microfilament/Myofilament
* Sarcomere

|

Cells|

* Myoblast/Myocyte
* Myosatellite cell

Other|

* Desmin
* Sarcoplasm
* Sarcolemma
* T-tubule
* Sarcoplasmic reticulum

Other/
ungrouped|

* Myotilin
* Telethonin
* Dysferlin
* Fukutin
* Fukutin-related protein

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