Iron overload disorder

ICD-10 | R79.0
ICD-9 | 790.6

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Contents

* 1 Overview
* 2 Causes
* 2.1 Primary iron overload
* 2.2 Secondary iron overload
* 2.3 Miscellaneous
* 3 See also
* 4 References
* 5 External links

## Overview

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In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.[1]

## Causes

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The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).[2]

### Primary iron overload

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Description | OMIM | Mutation

|
|

Haemochromatosis type 1: "classical"-haemochromatosis | 235200 | HFE
Haemochromatosis type 2A: juvenile haemochromatosis | 602390 | hemojuvelin ("HJV", also known as HFE2)
Haemochromatosis type 2B: juvenile haemochromatosis | 606464 | hepcidin antimicrobial peptide (HAMP) or HFE2B
Haemochromatosis type 3 | 604720 | transferrin receptor-2 (TFR2 or HFE3)
Haemochromatosis type 4 | 604653 | ferroportin (SLC11A3)
Neonatal haemochromatosis | 231100 | (unknown)
Aceruloplasminaemia (rare disease) | 604290 | ceruloplasmin
Congenital atransferrinaemia (rare disease) | 209300 | transferrin

### Secondary iron overload

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* Dietary iron overload
* Increased intake of drugs such as ferrous gluconate.
* Transfusional iron overload
* Long term haemodialysis
* Chronic liver disease
* Hepatitis C
* Alcoholic cirrhosis, especially when advanced
* Non-alcoholic steatohepatitis
* Porphyria cutanea tarda
* Post-portacaval shunting
* Dysmetabolic iron overload syndrome

### Miscellaneous

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The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online Mendelian Inheritance in Man (OMIM) 601195)

## See also

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* Iron deficiency
* Siderosis
* Human iron metabolism

## References

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1. ↑ Andrews NC (1999). "Disorders of iron metabolism". N. Engl. J. Med. 341 (26): 1986–95. PMID 10607817.
2. ↑ Pietrangelo A (2003). "Haemochromatosis". Gut. 52 Suppl 2: ii23–30. PMID 12651879.

## External links

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* Texas Medical Center
* Merck
* Iron Overload.org

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