Laryngeal cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Omer Kamal, M.D.[2], Faizan Sheraz, M.D. [3]

## Overview

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Laryngeal carcinoma may be classified into more than 14 subtypes based on the anatomical and histological characteristics of the tumor. Anatomical classification includes supraglottic, glottic and subglottic laryngeal cancer. Based on histology, laryngeal carcinoma may be classified into acantholytic squamous cell carcinoma, adenosquamous carcinoma, basaloid squamous cell carcinoma, papillary squamous cell carcinoma, spindle cell squamous cell carcinoma, verrucous carcinoma, giant cell carcinoma, lymphoepithelial carcinoma (non-nasopharyngeal), neuroendocrine carcinoma, typical carcinoid tumor (well differentiated neuroendocrine carcinoma) and atypical carcinoid tumor (moderately differentiated neuroendocrine carcinoma)

## Classification

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* Laryngeal carcinoma may be classified into more than 14 subtypes based on the anatomical and histological characteristics of the tumor.[1][2][3][4]

### Anatomical Classification of Laryngeal Carcinoma

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* Based on anatomy, laryngeal carcinoma may be classified into:[1][2][3][4]

| Laryngeal cancer|

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| Supraglottis|

| Glottis|

| Subglottis

### Histologic Classification of Laryngeal Carcinoma

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* Based on histology, laryngeal carcinoma may be classified into the following sub-types:[4][5]_SpringerLink-6|[6]

* Acantholytic squamous cell carcinoma
* Adenosquamous carcinoma
* Basaloid squamous cell carcinoma
* Papillary squamous cell carcinoma
* Spindle cell squamous cell carcinoma
* Verrucous carcinoma
* Giant cell carcinoma
* Lymphoepithelial carcinoma (non-nasopharyngeal)
* Neuroendocrine carcinoma
* Typical carcinoid tumor (well differentiated neuroendocrine carcinoma)
* Atypical carcinoid tumor (moderately differentiated neuroendocrine carcinoma)

## References

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1. ↑ 1.0 1.1 Thompson L (February 2006). "World Health Organization classification of tumours: pathology and genetics of head and neck tumours". Ear Nose Throat J. 85 (2): 74. PMID 16579185.
2. ↑ 2.0 2.1 Jaipuria B, Dosemane D, Kamath PM, Sreedharan SS, Shenoy VS (July 2018). "Staging of Laryngeal and Hypopharyngeal Cancer: Computed Tomography versus Histopathology". Iran J Otorhinolaryngol. 30 (99): 189–194. PMC 6064760. PMID 30083524.
3. ↑ 3.0 3.1 Lund C, Sogaard H, Jorgensen K, Hjelm-Hansen M (August 1976). "Epidermoid carcinoma of the larynx. VI. Histologic grading in the clinical evaluation". Acta Radiol Ther Phys Biol. 15 (4): 293–304. PMID 983778.
4. ↑ 4.0 4.1 4.2 Jakobsson PA, Eneroth CM, Killander D, Moberger G, Mårtensson B (February 1973). "Histologic classification and grading of malignancy in carcinoma of the larynx". Acta Radiol Ther Phys Biol. 12 (1): 1–8. PMID 4725642.
5. ↑ Ferlito A (1976). "Histological classification of larynx and hypopharynx cancers and their clinical implications. Pathologic aspects of 2052 malignant neoplasms diagnosed at the ORL Department of Padua University from 1966 to 1976". Acta Otolaryngol Suppl. 342: 1–88. PMID 195442.
6. _SpringerLink_6-0|↑ "Staging of laryngeal cancer: Endoscopy, computed tomography and magnetic resonance versus histopathology | SpringerLink".

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