Lead poisoning differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya Stevasarova, M.D.

## Overview[edit | edit source]

Lead poisoning must be differentiated from megaloblastic anemia[1], carpal tunnel syndrome[2], Guillain–Barré syndrome, renal colic, appendicitis, encephalitis in adults, and viral gastroenteritis in children.[3], constipation, abdominal colic[4], iron deficiency, subdural hematoma, neoplasms of the central nervous system, emotional and behavior disorders, and intellectual disability.[5] [6]

## Differentiating Lead poisoning from other Diseases[edit | edit source]

* As lead poisoning manifests in a variety of clinical forms, differentiation must be established in accordance with the particular clinical symptom. [7]
* Sideroblastic anemia must be differentiated from other diseases that cause basophilic stippling like megaloblastic anemia[1].
* Peripheral neuropathy must be differentiated from Guillain–Barré syndrome, which will present with albuminocytological dissociation on CSF analysis.
* Intellectual disability must be differentiated from autism, Down syndrome, Fragile X syndrome
* Abdominal colic must be differentiated from Gallbladder disease, viral gastroenteritis, pancreatitis etc.[4]

## References[edit | edit source]

1. ↑ 1.0 1.1 Fonte R, Agosti A, Scafa F, Candura SM (2007). "Anaemia and abdominal pain due to occupational lead poisoning". Haematologica. 92 (2): e13–4. PMID 17405745.CS1 maint: Multiple names: authors list (link)
2. ↑ Dsouza HS, Dsouza SA, Menezes G, Thuppil V (2009). "Evaluation and treatment of wrist drop in a patient due to lead poisoning: case report". Ind Health. 47 (6): 677–80. PMID 19996545.CS1 maint: Multiple names: authors list (link)
3. ↑
4. ↑ 4.0 4.1 Shiri R, Ansari M, Ranta M, Falah-Hassani K (2007). "Lead poisoning and recurrent abdominal pain". Ind Health. 45 (3): 494–6. PMID 17634699.CS1 maint: Multiple names: authors list (link)
5. ↑
6. ↑ Herman DS, Geraldine M, Venkatesh T (2007). "Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation". J Occup Med Toxicol. 2: 7. doi:10.1186/1745-6673-2-7. PMC 2000868. PMID 17718907.CS1 maint: Multiple names: authors list (link)
7. ↑ D'souza HS, Dsouza SA, Menezes G, Venkatesh T (2011). "Diagnosis, evaluation, and treatment of lead poisoning in general population". Indian J Clin Biochem. 26 (2): 197–201. doi:10.1007/s12291-011-0122-6. PMC 3107416. PMID 22468050.CS1 maint: Multiple names: authors list (link)

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