Leiomyosarcoma surgery

Leiomyosarcoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Leiomyosarcoma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Leiomyosarcoma surgery On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Leiomyosarcoma surgery

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Leiomyosarcoma surgery

CDC on Leiomyosarcoma surgery

Leiomyosarcoma surgery in the news

Blogs on Leiomyosarcoma surgery

Directions to Hospitals Treating Leiomyosarcoma

Risk calculators and risk factors for Leiomyosarcoma surgery

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:  Nima Nasiri, M.D.[2]

## Overview[edit | edit source]

Patients with leiomyosarcoma have many treatment options but surgery is considered the mainstay of treatment for all soft tissue sarcomas. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Treatment options are not chosen by the histological subtype of sarcoma but by tumor grade, size, and location of primary or metastatic disease.

## Surgery[edit | edit source]

* Surgery is mainstay of therapy in leiomyosarcoma patients, in case of recurrence or progression of disease combination therapy with chemoradiation can be used as well. [1]
* Surgical resection of local recurrence and pulmonary metastases should be considered in individual patients.[2]
* Hysterectomy with bilateral salpingoophorectomy has been the main effective way of surgical therapy in patients with leiomyosarcoma.[3]
* Lymphadenectomy is generally not required as the tumor usually metastasize hematogenously and rarely through the lymph nodes.[4][5][6]

| Established stage based on the result of physical exam, imaging and biopsy|

|
|
|
|
|
|
|
|
|

| Stage 1
low grade tumors|

| Stage 2
less than 5 cm
high grade tumor|

| Stage 3
more than 5 cm
high grade tumor or nodal disease|

| Stage 4
distant metastasis|

| Surgical resection|

| surgical resection
with or without radiation|

| surgical resection with radiation
with or without chemotherapy|

| chemotherapy
with or without surgical resection|

## References[edit | edit source]

1. ↑ Vrzic-Petronijevic S, Likic-Ladjevic I, Petronijevic M, Argirovic R, Ladjevic N (2006). "Diagnosis and surgical therapy of uterine sarcoma". Acta Chir Iugosl. 53 (3): 67–72. PMID 17338203.
2. ↑ Grimer, Robert; Judson, Ian; Peake, David; Seddon, Beatrice (2010). "Guidelines for the Management of Soft Tissue Sarcomas". Sarcoma. 2010: 1–15. doi:10.1155/2010/506182. ISSN 1357-714X.
3. ↑ "Treatment for Uterine Sarcoma, by Type and Stage".
4. ↑ Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007. J Cancer Res Clin Oncol 134 (12):1277-87. DOI:10.1007/s00432-008-0422-2 PMID: 18506484
5. ↑ Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus. Gynecol Oncol 91 (1):209-12. PMID: 14529683
6. ↑ "Uterine Sarcoma Stages".

Template:WikiDoc Sources