Low-dose chemotherapy

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## Contents

* 1 Overview
* 2 Forms of low-dose chemotherapy
* 2.1 Oral low-dose chemotherapy
* 2.2 Low-dose chemotherapy and antiangiogenesis
* 2.3 Insulin potentiation therapy low-dose chemotherapy
* 3 Research
* 4 Footnotes

## Overview

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Low-dose Chemotherapy is being studied/used in the treatment of cancer to avoid the devastating side effects of conventional chemotherapy. Historically, oncologists have used the highest possible dose that the body can tolerate in order to kill as many cancer cells as possible.[1] After high-dose treatments the body reacts, sometimes quite severely. Unfortunately normal cells, vital organs and the immune system often cannot tolerate the chemo's poisonous assault. Infections from external causes become a leading threat of death.

Some major pharmaceutical companies have spent hundreds of millions of dollars to get FDA approval for drugs to restore cancer patients' immune system.[2]

## Forms of low-dose chemotherapy

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The following forms of low-dose chemotherapy have been proposed. They are not always widely available treatments at hospitals.

### Oral low-dose chemotherapy

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Patients are given chemotherapy drugs orally very frequently. This approach can be very effective for some cancer and can minimize side effects for some people. More patients are using oral chemo than ever before.[3][4]

### Low-dose chemotherapy and antiangiogenesis

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Adam Dicker, M.D., Ph.D., associate professor, Jefferson Medical College of Thomas Jefferson University in Philadelphia, supports that chemotherapy is often used in the highest possible doses. They are rethinking chemotherapy because of the antiangiogenic effects of lowdose chemotherapy given on a more frequent basis than conventional chemo. They have shown excellent antiangiogenic results in the laboratory.[1]

### Insulin potentiation therapy low-dose chemotherapy

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Main article: Insulin potentiation therapy

Although yet to be proven, Insulin potentiation therapy (IPT) proponents suggest that insulin modifies cancer cells receptivity to being penetrated by the chemotherapy. Cancer cells secrete their own insulin and insulin-like growth factor (IGF) which work together to consume your body's nutrients to grow cancer. Cancer cell membranes have about sixteen times more insulin and IGF receptors than normal cells and these receptors react with synthetic insulin. When insulin is administered, the cancer starves for glucose and generates enzyme activity that makes the cell membrane more permeable. The chemotherapy drug gets absorbed by the cancer. By using the very same mechanisms that cancer cells use to grow and kill people, IPT channels the chemotherapy drug directly inside the cancer cells leaving normal cells alone.[5][6]

Insulin therapy is not the same as IPT Low-dose Chemotherapy. Insulin on its own modulates the transportation of nutrients and more throughout the body. There have been several attempts to use insulin in a variety functions that have proven ill advised.

## Research

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There are many other researchers looking for low-dose chemotherapy treatments.[7][8][9]

## Footnotes

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1. ↑ 1.0 1.1 "Jefferson Study Shows Low Concentrations of Chemotherapy Drugs Reduce Tumor Size and Have Antiangiogenic Effects". Kimmel Cancer Center, Jefferson Cancer Network. April 18, 2003. Retrieved 2006-10-22. \- study on mice in which human choriocarcinoma had been implanted
2. ↑ Cancer Therapy Evaluation Program. "Amgen Receives European Commission Approval For Both Aranesp® and Neulasta™ in Oncology -- These Unique, Long-Acting Molecules Represent Major Advances in Improving The Management of Anaemia and of Chemotherapy-Induced Infections". National Cancer Institute. Retrieved 2006-10-22.
3. ↑ "Oral Chemotherapy Will Play a Larger Role in Cancer Treatment". Medical News Today. 17 Aug 2005. Retrieved 2006-10-22.
4. ↑ Smith I , Johnston S, O'Brien M , Hickish T, de Boer R, Norton A, Cirkel D, Barton C (2000). "Low-Dose Oral Fluorouracil With Eniluracil as First-Line Chemotherapy Against Advanced Breast Cancer: A Phase II Study". Journal of Clinical Oncology. 18 (12): 2378–84. Unknown parameter `|month=` ignored (help)CS1 maint: Multiple names: authors list (link)
5. ↑ The Elka Best Foundation
6. ↑ Cancer Advisory Panel for Complementary and Alternative Medicine (CAPCAM) (September 18, 2000). "Minutes of the Third Meeting". National Centre for Complementary and Alternative Medicine. Retrieved 2006-10-22.
7. ↑ "Low Dose Chemotherapy". CancerProtocol.com. Retrieved 2006-10-22.
8. ↑ Lu W, Li Y, He X, Chen Y. "Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: evaluation of two kinds of dosages of anticancer drugs and analysis of prognostic factors". Hepatogastroenterology. 50 (54): 2079–83. PMID 14696468.CS1 maint: Multiple names: authors list (link)
9. ↑ Strum S (1999). "Important Principles in Chemotherapy: Regimens Treating And Androgen-Independent Prostate Cancer (AIPC)" (Reprint). PCRI Insights. 2 (4). Retrieved 2006-10-22. Unknown parameter `|month=` ignored (help)

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