MOCOS

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Identifiers
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Orthologs
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Wikidata
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Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the MOCOS gene.[1][2]

MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1), which is required for their enzymatic activities.[1]

## References

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1. ↑ 1.0 1.1 Ichida K, Matsumura T, Sakuma R, Hosoya T, Nishino T (Apr 2001). "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II". Biochem Biophys Res Commun. 282 (5): 1194–200. doi:10.1006/bbrc.2001.4719. PMID 11302742.
2. ↑ "Entrez Gene: MOCOS molybdenum cofactor sulfurase".

## Further reading

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* Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Yamamoto T, Moriwaki Y, Takahashi S (2003). "Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II". Metab. Clin. Exp. 52 (11): 1501–4. doi:10.1016/s0026-0495(03)00272-5. PMID 14624414.
* Beausoleil SA, Jedrychowski M, Schwartz D (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
* Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Beausoleil SA, Villén J, Gerber SA (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
* Peretz H, Naamati MS, Levartovsky D (2007). "Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria". Mol. Genet. Metab. 91 (1): 23–9. doi:10.1016/j.ymgme.2007.02.005. PMID 17368066.

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Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases|

* Thiosulfate sulfurtransferase
* Rhodanese
* 3-mercaptopyruvate sulfurtransferase
* thiosulfate—thiol sulfurtransferase
* tRNA sulfurtransferase
* thiosulfate—dithiol sulfurtransferase
* biotin synthase
* cysteine desulfurase

2.8.2: Sulfotransferases|

* Alcohol sulfotransferase
* Tyrosylprotein sulfotransferase
* Aryl sulfotransferase

2.8.3: CoA-transferases|

* Propionate CoA-transferase

2.8.4: Alkylthio|

* Coenzyme-B sulfoethylthiotransferase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)

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