MYOC

Myocilin, trabecular meshwork inducible glucocorticoid response

Identifiers
Symbols|  MYOC ; GLC1A; GPOA; JOAG; JOAG1; TIGR; myocilin
External IDs|  Template:OMIM5 Template:MGI HomoloGene: 220
| Gene ontology

Molecular function | Template:GNF GO Template:GNF GO Template:GNF GO
Cellular component | Template:GNF GO Template:GNF GO Template:GNF GO
Biological process | Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYOC 210155 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

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Myocilin, trabecular meshwork inducible glucocorticoid response, also known as MYOC, is a human gene.

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.[1]

## References[edit | edit source]

1. ↑ "Entrez Gene: MYOC myocilin, trabecular meshwork inducible glucocorticoid response".

## Further reading[edit | edit source]

* Fingert JH, Stone EM, Sheffield VC, Alward WL (2003). "Myocilin glaucoma". Survey of ophthalmology. 47 (6): 547–61. PMID 12504739.CS1 maint: Multiple names: authors list (link)
* Polansky JR (2004). "Current perspectives on the TIGR/MYOC gene (Myocilin) and glaucoma". Ophthalmology clinics of North America. 16 (4): 515–27, v–vi. PMID 14740993.
* Coca-Prados M, Escribano J (2007). "New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland". Progress in retinal and eye research. 26 (3): 239–62. doi:10.1016/j.preteyeres.2007.01.002. PMID 17321191.

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