Manchester score

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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Manchester score is an indicator of prognosis in small cell lung cancer.[1][2] It is calculated from a number of physical and biochemical markers.

A patient with small cell lung cancer scores one point for each of the following: -

* Serum lactate dehydrogenase exceeds the upper limit of the reference range.
* Serum sodium concentration less than 132 mmol/l.
* Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
* Serum bicarbonate less than 24.
* Karnofsky performance status less than 60.
* Extensive stage disease.

## Prognosis

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Prognosis of small cell lung cancer according to Manchester score[3] Manchester score | Prognostic group | Two year survival (%)

|
|

0-1  | Good  | 16.2
2-3  | Medium  | 2.5
4 or more  | Poor  | 0

## References

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1. ↑ Cerny, T (1987). "Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients". International Journal of Cancer. 39 (2): 146–149. Unknown parameter `|coauthors=` ignored (help)
2. ↑ Kawahara, Masaaki (1996). "Prognostic factors and prognostic staging system for small cell lung cancer". Japanese Journal of Clinical Oncology. Oxford University Press. 27 (3): 158–165. ISSN: 0368-2811. Unknown parameter `|coauthors=` ignored (help)
3. ↑ Maestu, I (Jun 1997). "Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients". Annals of Oncology. 8 (6): 547–553. Unknown parameter `|coauthors=` ignored (help)

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