Melanoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Yazan Daaboul, M.D.; Serge Korjian M.D.

## Overview[edit | edit source]

Symptoms of melanoma include a rapidly growing existing nevus, non-healing skin ulcers, pruritus, or bone pain.

## History and Symptoms[edit | edit source]

Symptoms of melanoma include the following:

* Rapid growth of an existing nevus[1]
* Bleeding nevus[1]
* Cutaneous nodules[2]
* Hyper/hypopigmented skin lesion
* Lymphatic masses
* Melanonychia (brown/blue nail discoloration)
* Non-healing skin ulcer[3][4]
* Painful skin lesion
* Pruritus[1]
* Bone pain[5][6]

## References[edit | edit source]

1. ↑ 1.0 1.1 1.2 Tromme I, Sacré L, Hammouch F, Richez P, Degryse JM, Speybroeck N (December 2018). "Melanoma diagnosis: predictive value of macroscopic changes observed by the patient". Melanoma Res. 28 (6): 611–617. doi:10.1097/CMR.0000000000000496. PMID 30192302.
2. ↑ Resende FS, Conforti C, Giuffrida R, de Barros MH, Zalaudek I (April 2018). "Raised vulvar lesions: be aware!". Dermatol Pract Concept. 8 (2): 158–161. doi:10.5826/dpc.0802a16. PMC 5955085. PMID 29785335.
3. ↑ Bønnelykke-Behrndtz ML, Schmidt H, Christensen IJ, Damsgaard TE, Møller HJ, Bastholt L, Nørgaard PH, Steiniche T (December 2014). "Prognostic stratification of ulcerated melanoma: not only the extent matters". Am. J. Clin. Pathol. 142 (6): 845–56. doi:10.1309/AJCPW56PHGLFTKZC. PMID 25389339.
4. ↑ Callender GG, McMasters KM (2011). "What does ulceration of a melanoma mean for prognosis?". Adv Surg. 45: 225–36. PMID 21954690.
5. ↑ Noor A, Cheng A, Sambrook P, Goss A (September 2018). "Melanoma Metastatic to the Mandible: Symptoms Precede Imaging Findings". J Maxillofac Oral Surg. 17 (3): 281–285. doi:10.1007/s12663-017-1000-4. PMID 30034144.
6. ↑ Narváez-Martínez Y, de la Ossa N, López-Martos R, Cohn-Reinoso C, Castellví-Juan M, Martin-Ferrer S (2017). "[Primary intramedullary melanoma: Case report and literature review]". Neurocirugia (Astur) (in Spanish; Castilian). 28 (4): 190–196. doi:10.1016/j.neucir.2017.01.003. PMID 28237771.CS1 maint: Unrecognized language (link)

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