MiR-155

pre-mir-155

File:MiR-155 secondary structure.png

pre-mir-155 secondary structure and sequence conservation.ard

Identifiers
Symbol| miR-155
Rfam| RF00731
miRBase family| MIPF0000157
Other data
RNA type| microRNA
Domain(s)| Eukaryota;
PDB structures| PDBe
VALUE_ERROR (nil)

Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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RefSeq (protein)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
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MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG.[1] MiR-155 plays a role in various physiological and pathological processes.[2][3][4][5][6][7] Exogenous molecular control in vivo of miR-155 expression may inhibit malignant growth,[8][9] viral infections,[10] and enhance the progression of cardiovascular diseases.[11]

## Contents

* 1 Discovery
* 2 Biogenesis
* 3 Evolutionary conservation
* 4 Tissue distribution
* 5 Targets
* 6 Physiological roles
* 6.1 Hematopoiesis
* 6.2 Immune system
* 7 Activity and phenotypes
* 8 Clinical significance
* 8.1 Cardiovascular
* 8.2 Immunity
* 8.2.1 Reduction of IgG1
* 8.2.2 Lymphocyte malignancies
* 8.3 Inflammation
* 8.4 DNA viruses
* 8.5 Cancer
* 9 Notes
* 10 See also
* 11 References
* 12 Further reading
* 13 External links

## Discovery

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The MIR155HG was initially identified as a gene that was transcriptionally activated by promoter insertion at a common retroviral integration site in B-cell lymphomas and was formerly called BIC (B-cell Integration Cluster). The MIR155HG is transcribed by RNA polymerase II and the resulting ~1,500 nucleotide RNA is capped and polyadenylated. The 23 nucleotide single-stranded miR-155, which is harbored in exon 3, is subsequently processed from the parent RNA molecule.[12]

File:Mir155 gene.pngFigure 1. Schematic representation of the MIR155HG (accession # NC_000021). This gene spans 13024 bp, is composed of three exons, and encodes a 1500 bp non-coding primary-miRNA (pri-miRNA) (accession # NR_001458). The location of the pre-mir-155 is denoted by the orange box.

## Biogenesis

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The MIR155HG RNA transcript does not contain a long open reading frame (ORF), however, it does include an imperfectly base-paired stem loop that is conserved across species.[13] This non-coding RNA (ncRNA) is now defined as a primary-miRNA (pri-miRNA).[13] Once miR-155 pri-miRNA is transcribed, this transcript is cleaved by the nuclear microprocessor complex, of which the core components are the RNase III type endonuclease Drosha and the DiGeorge critical region 8 (DGCR8) protein,[14][15] to produce a 65 nucleotide stem-loop precursor miRNA (pre-mir-155) (see Figure 2).

File:Pre-mir-155.pngFigure 2. The sequence of the pre-mir-155 stem loop that is matured from the pri-miRNA transcript. The mature miR-155 (miR-155-5p) sequence is shown in green and mature miR-155* (miR-155-3p) sequence is shown in red.

Following export from the nucleus by exportin-5, pre-mir-155 molecules are cleaved near the terminal loop by Dicer resulting in RNA duplexes of ~22nucleotides.[14][15] Following Dicer cleavage, an Argonaute (Ago) protein binds to the short RNA duplexes, forming the core of a multi-subunit complex called the RNA-induced silencing complex (RISC).[16] In a manner similar to siRNA duplexes, one of the two strands, the "passenger miRNA" (miR-155*), is released and degraded while the other strand, designated the "guide strand" or "mature miRNA" (miR-155), is retained within the RISC.[16]

Recent data suggest that both arms of the pre-miRNA hairpin can give rise to mature miRNAs.[17][18] Due to the increasing number of examples where two functional mature miRNAs are processed from opposite arms of the same pre-miRNA, pre-mir-155 products are now denoted with the suffix -5p (from the 5′ arm) (e.g. miR-155-5p) and -3p (from the 3′ arm) (e.g. miR-155-3p) following their name (see Figure 3).[19]

File:Mature mir-155-5p and -3p.pngFigure 3. The mature miR-155 (miR-155-5p) sequence is shown in green and mature miR-155* (miR-155-3p) sequence is shown in red.

Once miR-155-5p/-3p is assembled into the RISC, these molecules subsequently recognize their target messenger RNA (mRNA) by base pairing interactions between nucleotides 2 and 8 of miR-155-5p/-3p (the seed region) and complementary nucleotides predominantly in the 3'-untranslated region (3'-UTR) of mRNAs (see Figure 4 and 5 below).[20] Finally, with the miR-155-5p/-3p acting as an adaptor for the RISC, complex-bound mRNAs are subjected to translational repression (i.e. inhibition of translation initiation) and/or degradation following deadenylation.[16]

## Evolutionary conservation

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Early phylogenetic analyses demonstrated that the sequence of pre-mir-155 and miR-155-5p was conserved between human, mouse, and chicken.[13] Recent annotated sequencing data found that 22 different organisms including, mammals, amphibians, birds, reptiles, sea squirts, and sea lampreys, express a conserved miR-155-5p.[2] Currently much less sequence data is available regarding miR-155-3p, therefore, it is not clear how conserved this miRNA is across species.[3]

## Tissue distribution

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Northern blot analysis found that miR-155 pri-miRNA was abundantly expressed in the human spleen and thymus and detectable in the liver, lung, and kidney.[13] Subsequently, polymerase chain reaction (PCR) experiments demonstrated that miR-155-5p was detectable in all human tissues investigated.[21] Sequence analysis of small RNA clone libraries comparing miRNA expression to all other organ systems examined established that miR-155-5p was one of five miRNAs (i.e. miR-142, miR-144, miR-150, miR-155, and miR-223) that was specific for hematopoietic cells including B-cells, T-cells, monocytes and granulocytes.[22] Together these results suggest that miR-155-5p is expressed in a number of tissues and cell types and, therefore, may play a critical role in a wide variety of biological processes, including hematopoiesis [2][3][4]

Although very few studies have investigated the expression levels of miR-155-3p, Landgraf et al.[22] established that expression levels of this miRNA was very low in hematopoietic cells. Additionally, PCR analyses found that while miR-155-3p was detectable in a number of human tissues the expression levels of this miRNA were 20-200 fold less when compared to miR-155-5p levels.[23] Even though the function of miR-155-3p has been largely ignored, several studies now suggest that, in some cases (astrocytes and plasmacytoid dendritic cells), both miR-155-5p and -3p can be functionally matured from pre-mir-155.[24][25]

## Targets

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Bioinformatic analysis using TargetScan 6.2 (release date June, 2012) [4] revealed at least 4,174 putative human miR-155-5p mRNA targets exist, with a total of 918 conserved sites (i.e. between mouse and human) and 4,249 poorly conserved sites (i.e. human only).[20][26] Although the TargetScan 6.2 algorithm cannot be utilized to determine the miR-155-3p putative targets, one would speculate that this miRNA may also potentially regulate the expression of thousands of mRNA targets.

A comprehensive list of miR-155-5p/mRNA targets that were experimentally authenticated by both the demonstration of endogenous transcript regulation by miR-155-5p and validation of the miR-155-5p seed sequence through a reporter assay was recently assembled.[27] This list included 140 genes and included regulatory proteins for myelopoiesis and leukemogenesis (e.g. SHIP-1, AICDA, ETS1, JARID2, SPI1, etc.), inflammation (e.g. BACH1, FADD, IKBKE, INPP5D, MYD88, RIPK1, SPI1, SOCS, etc.) and known tumor suppressors (e.g. CEBPβ, IL17RB, PCCD4, TCF12, ZNF652, etc.).[27] The validated miR-155-5p binding site harbored in the SPI1 mRNA[28] and the validated miR-155-3p binding site harbored in the IRAK3 mRNA [25] are shown in Figures 4 and 5 respectively.

File:MiR-155-5p complementry binding with SPI1.pngFigure 4. Complementary base-pairing between miR-155-5p and the human SPI1 (spleen focus forming virus proviral integration oncogene)(also known as PU.1) mRNA. The miR-155-5p binding site is located 46-53 base pairs downstream from the SPI1 mRNA stop codon. The requisite "seed sequence" base-pairing is denoted by the bold dashes. File:IRAK3 and miR1553p.pngFigure 5. Complementary base-pairing between miR-155-3p and the human IRAK3 (interleukin-1 receptor-associated kinase 3) mRNA. The miR-155-3p binding site is located 424-430 base pairs downstream from the IRAK3 mRNA stop codon. The requisite "seed sequence" base-pairing is denoted by the bold dashes.

## Physiological roles

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### Hematopoiesis

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Hematopoiesis is defined as the formation and development of blood cells, all of which are derived from hematopoietic stem-progenitor cells (HSPCs).[29] HSPCs are primitive cells capable of self-renewal and initially differentiate into common myeloid progenitor (CMP) or common lymphoid progenitor (CLP) cells.[29] CMPs represent the cellular population that has become myeloid lineage and it is the point that myelopoeisis begins.[29] During myelopoeisis further cellular differentiation takes place including thrombopoiesis, erythropoeisis, granulopoeisis, and monocytopoeisis.[29] CLPs subsequently differentiate into B-cells and T-cells in a process designated lymphopoiesis.[29] Given that miR-155-5p is expressed in hematopoietic cells[22] it was hypothesized that this miRNA plays a critical role in these cellular differentiation processes. In support of this premise, miR-155-5p was found to be expressed in CD34(+) human HSPCs, and it was speculated that this miRNA may hold these cells at an early stem-progenitor stage, inhibiting their differentiation into a more mature cell (i.e. megakaryocytic/erythroid/granulocytic/monocytic/B-lymphoid/T-lymphoid).[30] This hypothesis was substantiated when pre-mir-155 transduced HSPCs generated 5-fold fewer myeloid and 3-fold fewer erythroid colonies.[30] Additionally, Hu et al.[31] demonstrated that the homeobox protein, HOXA9, regulated MIR155HG expression in myeloid cells and that this miRNA played a functional role in hematopoiesis. These investigators found that forced expression of miR-155-5p in bone marrow cells resulted in a ~50% decrease in SPI1 (i.e. PU.1),[31] a transcription factor and a regulator of myelopoiesis,[32] and a validated target of this miRNA.[28] It was also established that in vitro differentiation of purified human erythroid progenitor cells resulted in a progressive decrease of miR-155-5p expression in mature red cells.[33] Additionally, mice deficient in pre-mir-155 showed clear defects in lymphocyte development and generation of B- and T-cell responses in vivo.[28][34][35] Finally, it was established that regulatory T-cell (Tregs) development required miR-155-5p and this miRNA was shown to play a role in Treg homeostasis and overall survival by directly targeting SOCS1, a negative regulator for IL-2 signaling.[36][37] Taken together, these results strongly suggest that miR-155-5p is an essential molecule in the control of several aspects of hematopoiesis including myelopoiesis, erythropoiesis, and lymphopoiesis.

### Immune system

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The innate immune system constitutes the first line of defense against invading pathogens and is regarded as the major initiator of inflammatory responses.[38] Its cellular component involves primarily monocyte/macrophages, granulocytes, and dendritic cells (DCs), which are activated upon sensing of conserved pathogen structures (PAMPs) by pattern recognition receptors such as Toll-like receptors ((TLRs)).[39] MIR155HG (i.e. miR-155-5p) expression is greatly enhanced by TLR agonist stimulation of macrophages and dendritic cells.[40][41][42][43][44][45] Since microbial lipopolysaccharide (an agonist of TLR4) activates a chain of events that lead to the stimulation of the NF-κB and AP-1 transcription factors,[39] it was hypothesized that endotoxin activation of MIR155HG may be mediated by those transcription factors.[40] Indeed, MIR155HG expression was found to be activated in LPS treated murine macrophage cells (i.e. Raw264.7) by an NF-κB-mediated mechanism.[41] Furthermore, H. pylori infection of primary murine bone marrow-derived macrophages resulted in a NF-κB dependent up-regulation of MIR155HG.[46] In the context of viral infection vesicular stomatitis virus (VSV) challenge of murine peritoneal macrophages was reported to result in miR-155-5p over-expression via a retinoic acid-inducible gene I/JNK/NF-κB–dependent pathway.[47] Support for a role of AP-1 in MIR155HG activation comes from studies using stimuli relevant to viral infection such as TLR3 ligand poly(I:C) or interferon beta (IFN-β).[42] Downstream of those stimuli AP-1 seems to play a major role in MIR155HG activation.[42][48][49][50]

Upon its initiation via activation of e.g. TLRs by pathogen stimuli miR-155-5p functions as a post-transcriptional regulator of innate immune signaling pathways. Importantly, miR-155-5p displays a similar responsivenes to pathogen stimuli (e.g. TLR4 agonist LPS) as major pro-inflammatory marker mRNAs.[51] Once activated, miR-155-5p suppresses negative regulators of inflammation. These include inositol polyphosphate-5-phosphatase (INPP5D also denoted SHIP1) and suppressor of cytokine signaling 1 (SOCS1), suppression of which promotes cell survival, growth, migration, and anti-pathogen responses.[47][52][53][54] Besides supporting the activation of defense pathways miR-155-5p may also limit the strength of the resulting NF-κB dependent inflammatory response,[51] suggesting varying functions of miR-155 at different stages of inflammation.

Taken together, these observations imply that the activation of the MIR155HG may be context-dependent given that both AP-1- and NF-κB-mediated mechanisms regulate the expression of this gene. These studies also suggest that a broad range of viral and bacterial inflammatory mediators can stimulate the expression of miR-155-5p and indicate that there is an intimate relationship between inflammation, innate immunity and MIR155HG expression.

## Activity and phenotypes

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There is evidence that miR-155 participates in cascades associated with cardiovascular diseases and hypertension, and was also found to be implicated in immunity, genomic instability, cell differentiation, inflammation, virus associated infections and cancer.[citation needed]

Protective roles of miR-155 may arise in response to its action on silencing genes thereby regulating their expression time, mutations in miR-155 target site deny it the optimal access necessary to bring about gene silencing, leading to over abundance of delinquent activities that may go malignant, for example, miR-155 role as a protective agent against predisposition to B Cell associated malignancies is emphasized by maintaining the balance of Activation-Induced Cytidine Deaminase (AID) enzyme. MiR-155 mediates regulation of AID abundance and expression time upon immunological cues however, mutations in the target on AID mRNA result in its unresponsiveness to miR-155 silencing and lead to unbridled expression of its protein causing wild immature B-lymphocyte surges and AID-mediated chromosomal translocations.[3][4]

## Clinical significance

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### Cardiovascular

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Transfection of miR-155 into human primary lung fibroblasts reduces the endogenous expression of the angiotensin II receptor AT1R protein. Furthermore, AT1R mediates angiotensin II-related elevation in blood pressure and contributes to the pathogenesis of heart failure. Defective miR-155 function could be implicated in hypertension and cardiovascular diseases if the cis-regulatory site on 3` UTR of AT1R (miR-155 target site) was affected due to a SNP polymorphism in AT1R itself. This mutation is disruptive of miR-155 targeting and thus preventive of AT1R expression down-regulation.[3] In low blood pressure over-expression of miR-155 correlates with the impairment of AT1R activity.[2]

### Immunity

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miR-155 is involved in immunity by playing key roles in modulating humoral and innate cell-mediated immune responses, for example, In miR-155 deficient mice, immunological-memory is impaired; making it fall prey to repetitive bouts of invasions by the same pathogen (Rodriguez et al. 2007), maturation and specificity of miR-155-deficient B-lymphocytes are impaired since the process relies on AID enzyme which has a miR-155 target in its 3' UTR end.[3][4] The phenotypic consequences involving deficiency of miR-155 in mice show later in life where the animals develop lung and intestinal lesions.[2]

Activated B and T cells show increased miR-155 expression, the same goes for macrophages and dendritic cells of the immune system. MiR-155 is crucial for proper lymphocyte development and maturation. Details of various manifestations of miR-155 levels and involvement in activities that ascertain optimal immune responses have been the subject of many researches:

#### Reduction of IgG1

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Defective T and B cells as well as markedly decreased IgG1 responses were observed in miR-155-deficient mice, IgG1 is reduced whereas the expression of the IgM immunoglobulin remains normal in these mice. The change in IgG1 levels maybe explained by the fact that it is a target for miR-155 in B cells, the protein-encoding mRNA for the transcriptional regulator Pu.1-protein, elevation of Pu.1 protein predisposes defective IgG1 production. In addition to Pu.1, there are nearly 60 other differentially elevated genes in miR-155 deficient B cells, further inspection revealed possible miR-155 target sites in the 3' UTR regions in these genes.[4]

#### Lymphocyte malignancies

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Mature receptors affinity and specificity of lymphocytes to pathogenic agents underlie proper immune responses, optimal miR-155 coordination is required for manufacturing of normal B lymphocytes, production of high-affinity antibodies and balancing of BCR signalling. It has been demonstrated that miR-155 can be transferred through gap junctions from leukemic cells to healthy B cells and promote their transformation to tumorigenic-like cells [55]

Selection of competent B cells takes place in the germinal center where they are trained to differentiate body cells vs. foreign antigens, they compete for antigen recognition and for T cell help, in this fashion of selective pressure those B Cells that demonstrated high-affinity receptors and cooperation with T cells (affinity maturation) are recruited and deployed to the bone marrow or become memory B cells, apoptotic termination takes place for those B Cells failing the competition. Immature B cells which are miR-155 deficient evade apoptosis as a result of elevated Bcl-2 protein levels; a protein that was found to be involved in B Cell malignancies and to be controlled by miR-155.[4]

### Inflammation

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Inflammatory responses to triggers such as TNF-α involve macrophages with components that include miR-155. miR-155 is overexpressed in atopic dermatitis and contributes to chronic skin inflammation by increasing the proliferative response of T(H) cells through the downregulation of CTLA-4.[56] In Autoimmune disorders such as rheumatoid arthritis, miR-155 showed higher expression in patients' tissues and synovial fibroblasts.[2] In multiple sclerosis, increased expression of mir-155 has also been measured in peripheral and CNS-resident myeloid cells, including circulating blood monocytes and activated microglia.[57] It was also found that mir-155 is implicated in inflammation. Overexpression of mir-155 will lead to chronic inflammatory state in human.[58]

### DNA viruses

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In DNA viruses, miRNAs were experimentally verified, miRNAs in viruses are encoded by dsDNAs,[3] examples of such viruses include herpesviruses such as Humans-Epstein-Barr Virus (EBV) and adenoviruses,[2] another virus expressing miR-155-like miRNA in chickens is the oncogenic MDV-1 whose non-oncogenic relative MDV-2 does not, this suggests implication of miR-155 in lymphomagenesis.[3] Viruses can exploit host miRNAs to the degree that they use host miRNAs to encode for viral clones for example: miR-K12-11 in Kaposi's-sarcoma-associated Herpesvirus has a target specificity region orthologous to that of miR-155's; mimicking the action of miR-155 [59] and, sharing targets with it, thus it can be thought to suppress miR-155 accessibility to its targets by competition and this in effect downregulates expression of genes playing roles in cellular growth and apoptosis in a manner that defies regulations by miR-155.[2] EBV modulates host miR-155 expression, which is essential for growth of EBV-infected B cells.[60] EBV-infected cells have increased expression of miR-155 thereby disturbing equilibrium of expression for genes regulating transcription in those cells.[2][3]

### Cancer

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Over-silencing by miR-155 may result in triggering oncogenic cascades that begin by apoptotic resistance, the pro-apoptotic Tumour Protein-53-induced-nuclear-protein1 (TP53INP1) is silenced by miR-155, over-expression of miR-155 leads to decreased levels of TP53INP1 in pancreatic ductal adenocarcinomas and possibly in other epithelial cancers where TP53INP1 activity is lost thereby resulting in apoptosis evasion and uncontrolled bouts of growth.[3]

Inactivation of DNA Mismatch Repair (MMR) as identified by elevation of mutation rates is the cause of Lynch Syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), down-regulation of MMR controlling protein is carried out by over-expression of miR-155, MMR is controlled by a group of conserved proteins, reduced activity of these proteins results in elevated levels of mutations in the phenotype triggering a march towards developing this type of cancer.[61]

Other types of tumors in which miR-155 over-expression was reported include: thyroid carcinoma, breast cancer, colon cancer, cervical cancer, and lung cancer, where distinct miR-155 expression profiles quantification can potentially serve as signals for tumor detection and evaluation of prognosis outcome.[2] It is shown in an analysis that miR-155 expression is associated with survival in triple negative breast cancer.[62]

## Notes

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## See also

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* MicroRNA

## References

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1. ↑ "Entrez Gene: MIR155HG".
2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Faraoni I, Antonetti FR, Cardone J, Bonmassar E (Jun 2009). "miR-155 gene: a typical multifunctional microRNA". Biochimica et Biophysica Acta. 1792 (6): 497–505. doi:10.1016/j.bbadis.2009.02.013. PMID 19268705.
3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Teng G, Papavasiliou FN (Mar 2009). "Shhh! Silencing by microRNA-155". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364 (1517): 631–7. doi:10.1098/rstb.2008.0209. PMC 2660923. PMID 19008191.
4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Calame K (Dec 2007). "MicroRNA-155 function in B Cells". Immunity. 27 (6): 825–7. doi:10.1016/j.immuni.2007.11.010. PMID 18093533.
5. ↑ Tili E, Croce CM, Michaille JJ (2009). "miR-155: on the crosstalk between inflammation and cancer". International Reviews of Immunology. 28 (5): 264–84. doi:10.1080/08830180903093796. PMID 19811312.
6. ↑ O'Connell RM, Rao DS, Baltimore D (2012). "microRNA regulation of inflammatory responses". Annual Review of Immunology. 30: 295–312. doi:10.1146/annurev-immunol-020711-075013. PMID 22224773.
7. ↑ Elton TS, Selemon H, Elton SM, Parinandi NL (Dec 2013). "Regulation of the MIR155 host gene in physiological and pathological processes". Gene. 532 (1): 1–12. doi:10.1016/j.gene.2012.12.009. PMID 23246696.
8. ↑ Mattiske S, Suetani RJ, Neilsen PM, Callen DF (Aug 2012). "The oncogenic role of miR-155 in breast cancer". Cancer Epidemiology, Biomarkers & Prevention. 21 (8): 1236–43. doi:10.1158/1055-9965.EPI-12-0173. PMID 22736789.
9. ↑ Babar IA, Cheng CJ, Booth CJ, Liang X, Weidhaas JB, Saltzman WM, Slack FJ (Jun 2012). "Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): E1695–704. doi:10.1073/pnas.1201516109. PMC 3387084. PMID 22685206.
10. ↑ Wang L, Toomey NL, Diaz LA, Walker G, Ramos JC, Barber GN, Ning S (Aug 2011). "Oncogenic IRFs provide a survival advantage for Epstein-Barr virus- or human T-cell leukemia virus type 1-transformed cells through induction of BIC expression". Journal of Virology. 85 (16): 8328–37. doi:10.1128/JVI.00570-11. PMC 3147954. PMID 21680528.
11. ↑ Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S (Aug 2012). "MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis". Circulation Research. 111 (4): 415–25. doi:10.1161/CIRCRESAHA.112.267443. PMID 22715471.
12. ↑ Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE (Mar 2005). "Accumulation of miR-155 and BIC RNA in human B cell lymphomas". Proceedings of the National Academy of Sciences of the United States of America. 102 (10): 3627–32. doi:10.1073/pnas.0500613102. PMC 552785. PMID 15738415.
13. ↑ 13.0 13.1 13.2 13.3 Tam W (Aug 2001). "Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA". Gene. 274 (1–2): 157–67. doi:10.1016/S0378-1119(01)00612-6. PMID 11675008.
14. ↑ 14.0 14.1 Kim VN, Han J, Siomi MC (Feb 2009). "Biogenesis of small RNAs in animals". Nature Reviews Molecular Cell Biology. 10 (2): 126–39. doi:10.1038/nrm2632. PMID 19165215.
15. ↑ 15.0 15.1 Krol J, Loedige I, Filipowicz W (Sep 2010). "The widespread regulation of microRNA biogenesis, function and decay". Nature Reviews Genetics. 11 (9): 597–610. doi:10.1038/nrg2843. PMID 20661255.
16. ↑ 16.0 16.1 16.2 Fabian MR, Sonenberg N (Jun 2012). "The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC". Nature Structural & Molecular Biology. 19 (6): 586–93. doi:10.1038/nsmb.2296. PMID 22664986.
17. ↑ Bushati N, Cohen SM (2007). "microRNA functions". Annual Review of Cell and Developmental Biology. 23: 175–205. doi:10.1146/annurev.cellbio.23.090506.123406. PMID 17506695.
18. ↑ Filipowicz W, Bhattacharyya SN, Sonenberg N (Feb 2008). "Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?". Nature Reviews Genetics. 9 (2): 102–14. doi:10.1038/nrg2290. PMID 18197166.
19. ↑ Griffiths-Jones S (Jan 2004). "The microRNA Registry". Nucleic Acids Research. 32 (Database issue): D109–11. doi:10.1093/nar/gkh023. PMC 308757. PMID 14681370.
20. ↑ 20.0 20.1 Friedman RC, Farh KK, Burge CB, Bartel DP (Jan 2009). "Most mammalian mRNAs are conserved targets of microRNAs". Genome Research. 19 (1): 92–105. doi:10.1101/gr.082701.108. PMC 2612969. PMID 18955434.
21. ↑ Martin MM, Lee EJ, Buckenberger JA, Schmittgen TD, Elton TS (Jul 2006). "MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts". The Journal of Biological Chemistry. 281 (27): 18277–84. doi:10.1074/jbc.M601496200. PMC 3567671. PMID 16675453.
22. ↑ 22.0 22.1 22.2 Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T (Jun 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–14. doi:10.1016/j.cell.2007.04.040. PMC 2681231. PMID 17604727.
23. ↑ Elton TS, Sansom SE, Martin MM (2010). "Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins". RNA Biology. 7 (5): 540–7. doi:10.4161/rna.7.5.12685. PMC 3073250. PMID 21081842.
24. ↑ Tarassishin L, Loudig O, Bauman A, Shafit-Zagardo B, Suh HS, Lee SC (Dec 2011). "Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*". Glia. 59 (12): 1911–22. doi:10.1002/glia.21233. PMC 3241213. PMID 22170100.
25. ↑ 25.0 25.1 Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, Wu L, Shen N (Dec 2010). "miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells". Blood. 116 (26): 5885–94. doi:10.1182/blood-2010-04-280156. PMID 20852130.
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36. ↑ Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E (Mar 2009). "Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells". Journal of Immunology. 182 (5): 2578–82. doi:10.4049/jimmunol.0803162. PMID 19234151.
37. ↑ Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY (Jan 2009). "Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein". Immunity. 30 (1): 80–91. doi:10.1016/j.immuni.2008.11.010. PMC 2654249. PMID 19144316.
38. ↑ Medzhitov R (Mar 2010). "Inflammation 2010: new adventures of an old flame". Cell. 140 (6): 771–6. doi:10.1016/j.cell.2010.03.006. PMID 20303867.
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42. ↑ 42.0 42.1 42.2 O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D (Jan 2007). "MicroRNA-155 is induced during the macrophage inflammatory response". Proceedings of the National Academy of Sciences of the United States of America. 104 (5): 1604–9. doi:10.1073/pnas.0610731104. PMC 1780072. PMID 17242365.
43. ↑ Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P (Feb 2009). "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2735–40. doi:10.1073/pnas.0811073106. PMC 2650335. PMID 19193853.
44. ↑ Cremer TJ, Ravneberg DH, Clay CD, Piper-Hunter MG, Marsh CB, Elton TS, Gunn JS, Amer A, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S (2009). "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response". PLOS ONE. 4 (12): e8508. doi:10.1371/journal.pone.0008508. PMC 2794384. PMID 20041145.
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48. ↑ Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (Sep 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMID 20622002.
49. ↑ McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA (Jul 2010). "IL-10 inhibits miR-155 induction by toll-like receptors". The Journal of Biological Chemistry. 285 (27): 20492–8. doi:10.1074/jbc.M110.102111. PMC 2898307. PMID 20435894.
50. ↑ Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R (Sep 2009). "LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages". FASEB Journal. 23 (9): 2898–908. doi:10.1096/fj.09-131342. PMID 19423639.
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53. ↑ O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D (Apr 2009). "Inositol phosphatase SHIP1 is a primary target of miR-155". Proceedings of the National Academy of Sciences of the United States of America. 106 (17): 7113–8. doi:10.1073/pnas.0902636106. PMC 2678424. PMID 19359473.
54. ↑ Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM (Aug 2009). "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice". Blood. 114 (7): 1374–82. doi:10.1182/blood-2009-05-220814. PMC 2727407. PMID 19520806.
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56. ↑ Sonkoly E, Janson P, Majuri ML, Savinko T, Fyhrquist N, Eidsmo L, Xu N, Meisgen F, Wei T, Bradley M, Stenvang J, Kauppinen S, Alenius H, Lauerma A, Homey B, Winqvist O, Ståhle M, Pivarcsi A (Sep 2010). "MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4". The Journal of Allergy and Clinical Immunology. 126 (3): 581–9.e1-20. doi:10.1016/j.jaci.2010.05.045. PMID 20673989.
57. ↑ Moore CS, Rao VT, Durafourt BA, Bedell BJ, Ludwin SK, Bar-Or A, Antel JP (Nov 2013). "miR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization". Annals of Neurology. 74 (5): 709–20. doi:10.1002/ana.23967. PMID 23818336.
58. ↑ O'Connell RM, Rao DS, Baltimore D (2012). "microRNA regulation of inflammatory responses". Annual Review of Immunology. 30: 295–312. doi:10.1146/annurev-immunol-020711-075013. PMID 22224773.
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62. ↑ Lánczky, András; Nagy, Ádám; Bottai, Giulia; Munkácsy, Gyöngyi; Szabó, András; Santarpia, Libero; Győrffy, Balázs (2016-12-01). "miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients". Breast Cancer Research and Treatment. 160 (3): 439–446. doi:10.1007/s10549-016-4013-7. ISSN 1573-7217. PMID 27744485.

## Further reading

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* Wang G, Tam LS, Li EK, Kwan BC, Chow KM, Luk CC, Li PK, Szeto CC (Dec 2010). "Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus". The Journal of Rheumatology. 37 (12): 2516–22. doi:10.3899/jrheum.100308. PMID 20952466.
* Kutty RK, Nagineni CN, Samuel W, Vijayasarathy C, Hooks JJ, Redmond TM (Nov 2010). "Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway". Biochemical and Biophysical Research Communications. 402 (2): 390–5. doi:10.1016/j.bbrc.2010.10.042. PMC 2992362. PMID 20950585.
* Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, Tsuruga K, Aizawa-Yashiro T, Hayakari R, Inoue I, Ito E, Satoh K (2010). "IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells". American Journal of Nephrology. 32 (5): 462–8. doi:10.1159/000321365. PMID 20948191.
* Thompson RC, Herscovitch M, Zhao I, Ford TJ, Gilmore TD (Jan 2011). "NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway". The Journal of Biological Chemistry. 286 (3): 1675–82. doi:10.1074/jbc.M110.177063. PMC 3023462. PMID 20947507.
* Wang P, Hou J, Lin L, Wang C, Liu X, Li D, Ma F, Wang Z, Cao X (Nov 2010). "Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1". Journal of Immunology. 185 (10): 6226–33. doi:10.4049/jimmunol.1000491. PMID 20937844.
* O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D (Oct 2010). "MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development". Immunity. 33 (4): 607–19. doi:10.1016/j.immuni.2010.09.009. PMC 2966521. PMID 20888269.
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* Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, Wu L, Shen N (Dec 2010). "miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells". Blood. 116 (26): 5885–94. doi:10.1182/blood-2010-04-280156. PMID 20852130.
* Linnstaedt SD, Gottwein E, Skalsky RL, Luftig MA, Cullen BR (Nov 2010). "Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus". Journal of Virology. 84 (22): 11670–8. doi:10.1128/JVI.01248-10. PMC 2977875. PMID 20844043.
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* Bolisetty MT, Dy G, Tam W, Beemon KL (Dec 2009). "Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival". Journal of Virology. 83 (23): 12009–17. doi:10.1128/JVI.01182-09. PMC 2786729. PMID 19759154.
* Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST (Oct 2009). "Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice". Hepatology. 50 (4): 1152–61. doi:10.1002/hep.23100. PMC 2757532. PMID 19711427.
* Pottier N, Maurin T, Chevalier B, Puisségur MP, Lebrigand K, Robbe-Sermesant K, Bertero T, Lino Cardenas CL, Courcot E, Rios G, Fourre S, Lo-Guidice JM, Marcet B, Cardinaud B, Barbry P, Mari B (2009). "Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions". PLOS ONE. 4 (8): e6718. doi:10.1371/journal.pone.0006718. PMC 2726943. PMID 19701459.
* Xiao B, Liu Z, Li BS, Tang B, Li W, Guo G, Shi Y, Wang F, Wu Y, Tong WD, Guo H, Mao XH, Zou QM (Sep 2009). "Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response". The Journal of Infectious Diseases. 200 (6): 916–25. doi:10.1086/605443. PMID 19650740.
* Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S, Elmén J, Hedtjärn M, Straarup EM, Hansen JB, Kauppinen S (Sep 2009). "Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF". Nucleic Acids Research. 37 (17): 5784–92. doi:10.1093/nar/gkp577. PMC 2761263. PMID 19596814.
* Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM (Aug 2009). "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice". Blood. 114 (7): 1374–82. doi:10.1182/blood-2009-05-220814. PMC 2727407. PMID 19520806.
* Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R (Sep 2009). "LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages". FASEB Journal. 23 (9): 2898–908. doi:10.1096/fj.09-131342. PMID 19423639.
* Martinez-Nunez RT, Louafi F, Friedmann PS, Sanchez-Elsner T (Jun 2009). "MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)". The Journal of Biological Chemistry. 284 (24): 16334–42. doi:10.1074/jbc.M109.011601. PMC 2713543. PMID 19386588.
* O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D (Apr 2009). "Inositol phosphatase SHIP1 is a primary target of miR-155". Proceedings of the National Academy of Sciences of the United States of America. 106 (17): 7113–8. doi:10.1073/pnas.0902636106. PMC 2678424. PMID 19359473.
* Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E (Mar 2009). "Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells". Journal of Immunology. 182 (5): 2578–82. doi:10.4049/jimmunol.0803162. PMID 19234151.
* Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P (Feb 2009). "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2735–40. doi:10.1073/pnas.0811073106. PMC 2650335. PMID 19193853.
* Habbe N, Koorstra JB, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG, Hong SM, Maitra A (Feb 2009). "MicroRNA miR-155 is a biomarker of early pancreatic neoplasia". Cancer Biology & Therapy. 8 (4): 340–6. doi:10.4161/cbt.8.4.7338. PMC 2692997. PMID 19106647.
* Jung I, Aguiar RC (Jan 2009). "MicroRNA-155 expression and outcome in diffuse large B-cell lymphoma". British Journal of Haematology. 144 (1): 138–40. doi:10.1111/j.1365-2141.2008.07424.x. PMID 19016736.
* Romania P, Lulli V, Pelosi E, Biffoni M, Peschle C, Marziali G (Nov 2008). "MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors". British Journal of Haematology. 143 (4): 570–80. doi:10.1111/j.1365-2141.2008.07382.x. PMID 18950466.
* Zhao Y, Yao Y, Xu H, Lambeth L, Smith LP, Kgosana L, Wang X, Nair V (Jan 2009). "A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus". Journal of Virology. 83 (1): 489–92. doi:10.1128/JVI.01166-08. PMC 2612317. PMID 18945769.
* Gatto G, Rossi A, Rossi D, Kroening S, Bonatti S, Mallardo M (Nov 2008). "Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway". Nucleic Acids Research. 36 (20): 6608–19. doi:10.1093/nar/gkn666. PMC 2582607. PMID 18940871.
* Rahadiani N, Takakuwa T, Tresnasari K, Morii E, Aozasa K (Dec 2008). "Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell lines". Biochemical and Biophysical Research Communications. 377 (2): 579–83. doi:10.1016/j.bbrc.2008.10.007. PMID 18926796.
* Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ (Nov 2008). "MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA". Molecular and Cellular Biology. 28 (22): 6773–84. doi:10.1128/MCB.00941-08. PMC 2573297. PMID 18794355.
* Lu F, Weidmer A, Liu CG, Volinia S, Croce CM, Lieberman PM (Nov 2008). "Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence". Journal of Virology. 82 (21): 10436–43. doi:10.1128/JVI.00752-08. PMC 2573162. PMID 18753206.
* Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC (May 2008). "MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation". Immunity. 28 (5): 630–8. doi:10.1016/j.immuni.2008.04.002. PMC 2713656. PMID 18455451.
* Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN (May 2008). "MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase". Immunity. 28 (5): 621–9. doi:10.1016/j.immuni.2008.03.015. PMC 2430982. PMID 18450484.
* Yin Q, McBride J, Fewell C, Lacey M, Wang X, Lin Z, Cameron J, Flemington EK (Jun 2008). "MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways". Journal of Virology. 82 (11): 5295–306. doi:10.1128/JVI.02380-07. PMC 2395216. PMID 18367535.
* Zhang T, Nie K, Tam W (Sep 2008). "BIC is processed efficiently to microRNA-155 in Burkitt lymphoma cells". Leukemia. 22 (9): 1795–7. doi:10.1038/leu.2008.62. PMID 18354490.
* Wang M, Tan LP, Dijkstra MK, van Lom K, Robertus JL, Harms G, Blokzijl T, Kooistra K, van T'veer MB, Rosati S, Visser L, Jongen-Lavrencic M, Kluin PM, van den Berg A (May 2008). "miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression". The Journal of Pathology. 215 (1): 13–20. doi:10.1002/path.2333. PMID 18348159.
* O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, Paquette RL, Baltimore D (Mar 2008). "Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder". The Journal of Experimental Medicine. 205 (3): 585–94. doi:10.1084/jem.20072108. PMC 2275382. PMID 18299402.
* Rai D, Karanti S, Jung I, Dahia PL, Aguiar RC (Feb 2008). "Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma". Cancer Genetics and Cytogenetics. 181 (1): 8–15. doi:10.1016/j.cancergencyto.2007.10.008. PMC 2276854. PMID 18262046.
* Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros WH, Chi JT, Braich R, Manoharan M, Soutschek J, Ohler U, Cullen BR (Dec 2007). "A viral microRNA functions as an orthologue of cellular miR-155". Nature. 450 (7172): 1096–9. doi:10.1038/nature05992. PMC 2614920. PMID 18075594.
* Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M (Dec 2007). "microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells". Immunity. 27 (6): 847–59. doi:10.1016/j.immuni.2007.10.009. PMID 18055230.
* Yin Q, Wang X, McBride J, Fewell C, Flemington E (Feb 2008). "B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element". The Journal of Biological Chemistry. 283 (5): 2654–62. doi:10.1074/jbc.M708218200. PMC 2810639. PMID 18048365.
* Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, Croce CM (Oct 2007). "Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock". Journal of Immunology. 179 (8): 5082–9. doi:10.4049/jimmunol.179.8.5082. PMID 17911593.
* Gironella M, Seux M, Xie MJ, Cano C, Tomasini R, Gommeaux J, Garcia S, Nowak J, Yeung ML, Jeang KT, Chaix A, Fazli L, Motoo Y, Wang Q, Rocchi P, Russo A, Gleave M, Dagorn JC, Iovanna JL, Carrier A, Pébusque MJ, Dusetti NJ (Oct 2007). "Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16170–5. doi:10.1073/pnas.0703942104. PMC 2042180. PMID 17911264.
* Skalsky RL, Samols MA, Plaisance KB, Boss IW, Riva A, Lopez MC, Baker HV, Renne R (Dec 2007). "Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155". Journal of Virology. 81 (23): 12836–45. doi:10.1128/JVI.01804-07. PMC 2169101. PMID 17881434.
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## External links

[edit | edit source]

* miRBase
* miRBase entries for all known mir-155
*   * Page for mir-155 microRNA precursor family at Rfam

* v
* t
* e

miRNA precursor families

1-100|

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* 8/141/200
* 9/79
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* 15
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* 46/47/281
* 92
* 96

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201+|

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* 296
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* 395
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* 433
* 451

Other|

* BART1
* BART2
* BHRF1-1
* BHRF1-2
* BHRF1-3
* Let-7
* Lin-4
* Lsy-6

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template