Multiple myeloma other imaging findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]

## Overview[edit | edit source]

Positron emission tomography (PET) scan may be diagnostic of multiple myeloma. Findings on PET scan suggestive of multiple myeloma include uptake of the F18-FDG molecule by lesions of bone lysis seen on PET-CT scan.

## Positron Emission Tomography Scan[edit | edit source]

* Positron emission tomography (PET) scan is a highly sensitive and specific diagnostic tool for diagnosing multiple myeloma.[1][2][3][4]
* Uptake of the F18-FDG molecule by lesions of multiple myeloma corresponds to areas of bone lysis seen on PET-CT scan.[5][3]
* PET scan is superior to either CT scan or X-ray for diagnosis of lytic lesions of multiple myeloma.[1][2][4]
* PET scan is useful in the detection of cancer spread to distant lymph nodes.[1][2]
* PET scan assess for spleen involvement more readily than other imaging modalities.
* The use of PET scan has led to earlier diagnosis of multiple myeloma and increased the accuracy of therapy response assessment.[6]
* PET scan has still not been employed as a standard of care by the International Myeloma Working Group.[6]

## References[edit | edit source]

1. ↑ 1.0 1.1 1.2 Shortt CP, Gleeson TG, Breen KA, McHugh J, O'Connell MJ, O'Gorman PJ; et al. (2009). "Whole-Body MRI versus PET in assessment of multiple myeloma disease activity". AJR Am J Roentgenol. 192 (4): 980–6. doi:10.2214/AJR.08.1633. PMID 19304704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
2. ↑ 2.0 2.1 2.2 Agarwal A, Chirindel A, Shah BA, Subramaniam RM (2013). "Evolving role of FDG PET/CT in multiple myeloma imaging and management". AJR Am J Roentgenol. 200 (4): 884–90. doi:10.2214/AJR.12.9653. PMID 23521465.CS1 maint: Multiple names: authors list (link)
3. ↑ 3.0 3.1 Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S (July 2016). "The Diagnosis and Treatment of Multiple Myeloma". Dtsch Arztebl Int. 113 (27–28): 470–6. doi:10.3238/arztebl.2016.0470. PMC 4973001. PMID 27476706.
4. ↑ 4.0 4.1 Diagnosing multiple myeloma. Canadian Cancer Society (2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015
5. ↑ Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015
6. ↑ 6.0 6.1 Dimopoulos M, Terpos E, Comenzo RL, Tosi P, Beksac M, Sezer O; et al. (2009). "International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma". Leukemia. 23 (9): 1545–56. doi:10.1038/leu.2009.89. PMID 19421229.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)