Mycobacterium intracellulare

Scientific classification
| Kingdom:  | Bacteria

|

Phylum:  | Actinobacteria

Order:  | Actinomycetales

Suborder:  | Corynebacterineae

Family:  | Mycobacteriaceae

Genus:  | Mycobacterium

Species:  | M. intracellulare

Binomial name
Mycobacterium intracellulare
Runyon 1965, ATCC 13950

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Mycobacterium intracellulare

## Contents

* 1 Description
* 2 Pathogenesis
* 3 Type Strain
* 4 References

## Description

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Gram-positive, nonmotile and acid-fast short to long rods.

Colony characteristics

* Usually smooth, rarely rough and nonpigmented colonies. Ageing colonies may become yellow.

Physiology

* Growth on Löwenstein-Jensen medium and Middlebrook 7H10 at 37°C after 7 or more days.
* Resistant to isoniazid, ethambutol, rifampin and streptomycin.

Differential characteristics

* M. intracellulare and M. avium form the M. avium-intracellulare complex (MAIC). A commercially available hybridisation assay (AccuProbe) to identify all members of the MAIC exists. Furthermore, separate AccuProbes are available to identify either M. intracellulare or M. avium.
* remarkable ITS heterogeneity within different M. intracellulare isolates.

## Pathogenesis

[edit | edit source]

* Most frequently encountered in pulmonary secretions from patients suffering from tuberculosis like disease and from surgical specimens from such patients.
* When isolated from human secretions, it is often the etiologic agent of pulmonary disease, although frequently isolated as apparent casual resident
* Biosafety level 2

## Type Strain

[edit | edit source]

* First isolated from fatal systemic disease in a child. Found in soil and water.

Strain ATCC 13950 = CCUG 28005 = CIP 104243 = DSM 43223 = JCM 6384 = NCTC 13025.

## References

[edit | edit source]

* Cuttino, J., A. McCabe. 1949. Pure granulomatous nocardiosis: A new fungus disease distinguished by intracellular parasitism. American Journal of Clinical Pathology, 25, 1-34.
* Runyon, E. 1965\. Pathogenic mycobacteria. Advances in Tuberculosis Research, 14, 235-287.

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