NAGK

N-acetylglucosamine kinase

File:PBB Protein NAGK image.jpg

PDB rendering based on 2ch5.

| Available structures

PDB |  Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
| List of PDB id codes

2ch5​, 2ch6​

Identifiers
Symbols|  NAGK ; GNK; HSA242910
External IDs|  Template:OMIM5 Template:MGI HomoloGene: 9720
| Gene ontology

Molecular function | Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Cellular component | Template:GNF GO
Biological process | Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NAGK 218231 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

N-acetylglucosamine kinase, also known as NAGK, is a human gene.[1]

N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.[supplied by OMIM][1]

## References

[edit | edit source]

1. ↑ 1.0 1.1 "Entrez Gene: NAGK N-acetylglucosamine kinase".

## Further reading

[edit | edit source]

* Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
* Weidanz JA, Campbell P, Moore D; et al. (1997). "N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum". Br. J. Haematol. 95 (4): 645–53. PMID 8982040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lowes W, Walker M, Alberti KG, Agius L (1998). "Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis". Biochim. Biophys. Acta. 1379 (1): 134–42. PMID 9468341.CS1 maint: Multiple names: authors list (link)
* Hinderlich S, Berger M, Schwarzkopf M; et al. (2000). "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase". Eur. J. Biochem. 267 (11): 3301–8. PMID 10824116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ligos JM, de Lera TL, Hinderlich S; et al. (2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". J. Biol. Chem. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Maguire PB, Wynne KJ, Harney DF; et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6&lt;642::AID-PROT642&gt;3.0.CO;2-I. PMID 12112843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
* Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Sparks SE, Ciccone C, Lalor M; et al. (2006). "Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy". Glycobiology. 15 (11): 1102–10. doi:10.1093/glycob/cwi100. PMID 15987957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Weihofen WA, Berger M, Chen H; et al. (2007). "Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation". J. Mol. Biol. 364 (3): 388–99. doi:10.1016/j.jmb.2006.08.085. PMID 17010375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

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