Narcolepsy medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Muhammad Waleed Haider, M.D.[2]

## Overview

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There is no treatment for [disease name]; the mainstay of therapy is supportive care.

Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].

The majority of cases of [disease name] are self-limited and require only supportive care.

[Disease name] is a medical emergency and requires prompt treatment.

The mainstay of treatment for [disease name] is [therapy].

OR  The optimal therapy for [malignancy name] depends on the stage at diagnosis.

[Therapy] is recommended among all patients who develop [disease name].

Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].

Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].

Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].

Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].

## Medical Therapy

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* Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].
* Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
* Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].
* Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].

### Disease Name

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* 1 Stage 1 - Name of stage
* 1.1 Specific Organ system involved 1
* 1.1.1 Adult
* Preferred regimen (1): drug name 100 mg PO q12h for 10-21 days (Contraindications/specific instructions)
* Preferred regimen (2): drug name 500 mg PO q8h for 14-21 days
* Preferred regimen (3): drug name 500 mg q12h for 14-21 days
* Alternative regimen (1): drug name 500 mg PO q6h for 7–10 days
* Alternative regimen (2): drug name 500 mg PO q12h for 14–21 days
* Alternative regimen (3): drug name 500 mg PO q6h for 14–21 days
* 1.1.2 Pediatric
* 1.1.2.1 (Specific population e.g. children < 8 years of age)
* Preferred regimen (1): drug name 50 mg/kg PO per day q8h (maximum, 500 mg per dose)
* Preferred regimen (2): drug name 30 mg/kg PO per day in 2 divided doses (maximum, 500 mg per dose)
* Alternative regimen (1): drug name10 mg/kg PO q6h (maximum, 500 mg per day)
* Alternative regimen (2): drug name 7.5 mg/kg PO q12h (maximum, 500 mg per dose)
* Alternative regimen (3): drug name 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
* 1.1.2.2 (Specific population e.g. 'children < 8 years of age')
* Preferred regimen (1): drug name 4 mg/kg/day PO q12h（maximum, 100 mg per dose）
* Alternative regimen (1): drug name 10 mg/kg PO q6h (maximum, 500 mg per day)
* Alternative regimen (2): drug name 7.5 mg/kg PO q12h (maximum, 500 mg per dose)
* Alternative regimen (3): drug name 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
* 1.2 Specific Organ system involved 2
* 1.2.1 Adult
* Preferred regimen (1): drug name 500 mg PO q8h
* 1.2.2 Pediatric
* Preferred regimen (1): drug name 50 mg/kg/day PO q8h (maximum, 500 mg per dose)

* 2 Stage 2 - Name of stage
* 2.1 Specific Organ system involved 1

Note (1):
Note (2):
Note (3):
* 2.1.1 Adult
* Parenteral regimen
* Preferred regimen (1): drug name 2 g IV q24h for 14 (14–21) days
* Alternative regimen (1): drug name 2 g IV q8h for 14 (14–21) days
* Alternative regimen (2): drug name 18–24 MU/day IV q4h for 14 (14–21) days
* Oral regimen
* Preferred regimen (1): drug name 500 mg PO q8h for 14 (14–21) days
* Preferred regimen (2): drug name 100 mg PO q12h for 14 (14–21) days
* Preferred regimen (3): drug name 500 mg PO q12h for 14 (14–21) days
* Alternative regimen (1): drug name 500 mg PO q6h for 7–10 days
* Alternative regimen (2): drug name 500 mg PO q12h for 14–21 days
* Alternative regimen (3):drug name 500 mg PO q6h for 14–21 days
* 2.1.2 Pediatric
* Parenteral regimen
* Preferred regimen (1): drug name 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
* Alternative regimen (1): drug name 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
* Alternative regimen (2):  drug name 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day) '(Contraindications/specific instructions)'
* Oral regimen
* Preferred regimen (1): drug name 50 mg/kg/day PO q8h for 14 (14–21) days (maximum, 500 mg per dose)
* Preferred regimen (2): drug name (for children aged ≥ 8 years) 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
* Preferred regimen (3): drug name 30 mg/kg/day PO q12h for 14 (14–21) days (maximum, 500 mg per dose)
* Alternative regimen (1): drug name 10 mg/kg PO q6h 7–10 days (maximum, 500 mg per day)
* Alternative regimen (2): drug name 7.5 mg/kg PO q12h for 14–21 days (maximum, 500 mg per dose)
* Alternative regimen (3): drug name 12.5 mg/kg PO q6h for 14–21 days (maximum,500 mg per dose)
* 2.2 'Other Organ system involved 2'

Note (1):
Note (2):
Note (3):
* 2.2.1 Adult
* Parenteral regimen
* Preferred regimen (1): drug name 2 g IV q24h for 14 (14–21) days
* Alternative regimen (1): drug name 2 g IV q8h for 14 (14–21) days
* Alternative regimen (2): drug name 18–24 MU/day IV q4h for 14 (14–21) days
* Oral regimen
* Preferred regimen (1): drug name 500 mg PO q8h for 14 (14–21) days
* Preferred regimen (2): drug name 100 mg PO q12h for 14 (14–21) days
* Preferred regimen (3): drug name 500 mg PO q12h for 14 (14–21) days
* Alternative regimen (1): drug name 500 mg PO q6h for 7–10 days
* Alternative regimen (2): drug name 500 mg PO q12h for 14–21 days
* Alternative regimen (3):drug name 500 mg PO q6h for 14–21 days
* 2.2.2 Pediatric
* Parenteral regimen
* Preferred regimen (1): drug name 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
* Alternative regimen (1): drug name 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
* Alternative regimen (2):  drug name 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day)
* Oral regimen
* Preferred regimen (1): drug name 50 mg/kg/day PO q8h for 14 (14–21) days (maximum, 500 mg per dose)
* Preferred regimen (2): drug name 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
* Preferred regimen (3): drug name 30 mg/kg/day PO q12h for 14 (14–21) days (maximum, 500 mg per dose)
* Alternative regimen (1): drug name 10 mg/kg PO q6h 7–10 days (maximum, 500 mg per day)
* Alternative regimen (2): drug name 7.5 mg/kg PO q12h for 14–21 days (maximum, 500 mg per dose)
* Alternative regimen (3): drug name 12.5 mg/kg PO q6h for 14–21 days (maximum,500 mg per dose)

## References

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