Nicotinic antagonist

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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A nicotinic antagonist is a type of anticholinergic which inhibits the action at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, but some centrally acting compounds such as mecamylamine and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and can be used for treating drug addiction.

Comparison  Mechanism  | Antagonist  | Preferred receptor  | Clinical use

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|
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Ganglionic blocking agents | Hexamethonium | Ganglion type | none[1]
Mecamylamine | Ganglion type |
Trimethaphan | Ganglion type | Rarely used for blood pressure decrease during surgery[1]
Nondepolarizing neuromuscular blocking agents | Atracurium | Muscle type | muscle relaxant in anaesthesia[1]
Doxacurium | Muscle type |
Mivacurium | Muscle type |
Pancuronium | Muscle type | muscle relaxant in anaesthesia[1]
Tubocurarine | Muscle type | Rarely used [1]
Vecuronium | Muscle type | muscle relaxant in anaesthesia[1]
Depolarizing neuromuscular blocking agents | Succinylcholine | Muscle type |
Centrally acting nicotinic antagonists  | 18-Methoxycoronaridine | α3β4  |

## References

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1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 149

## External links

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* Nicotinic+antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)

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Antihypertensives (C02) and diuretics (C03)

Sympatholytic agents|

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Vasodilators|

Diazoxide • hydrazinophthalazine (Hydralazine, Dihydralazine, Endralazine, Cadralazine) • Minoxidil • Nitroprusside • Phentolamine

Other antihypertensives|

serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) • MAOI (Pargyline) • THI (Metirosine)

Diuretics|

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Skeletal Muscle relaxants (M03)

Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs)|

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Centrally Acting|

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Directly acting|

Dantrolene

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