Osteonecrosis of the jaw overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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Osteonecrosis of the jaws (ONJ) is a severe bone disease that affects the jaws, including the maxilla and the mandible. Jaw bone (osteo-) damage and death (-necrosis) occurs as a result of reduced local blood supply (ischemia). The condition is thus included in the general category of ischemic or avascular osteonecrosis (literally "dead bone from poor blood flow."). Various forms of ONJ have been described over the last 160 years, and a number of causes have been suggested in the literature. In recent years, an increased incidence of ONJ has been associated with the use of high dosages of bisphosphonates, required by some cancer treatment regimens, especially when the patient undergoes subsequent dental procedures. The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis, remains uncertain.[1] Various treatment options have been explored, however severe cases of ONJ still require surgical removal of the affected bone.[2] Careful anamnesis (patient history) and assessement of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.[1]

## References

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1. ↑ 1.0 1.1 Woo S, Hellstein J, Kalmar J (2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws". Ann Intern Med. 144 (10): 753–61. PMID 16702591.CS1 maint: Multiple names: authors list (link)
2. ↑ Bouquot JE, Christian J. Long-term effects of jawbone curettage on the pain of facial neuralgia. J Oral Maxillofac Surg 1995; 53:387-397. PMID: 7699492