Oxygen intoxication

Oxygen intoxication is known to be caused by the inhaling of high concentration oxygen for a long period of time. However it is not a threat to humans in normal physiological conditions. Oxygen intoxication can occur only when gas pressure is at an elevated amount. Under normal atmospheric pressure there is no effect and the concentration of 20%-50% is absolutely safe. Furthermore that of 100% is also safe within 10 hours.[1] [2] However when comparing animal studies with the lungs of human patients who have died after prolonged oxygen therapy, it was shown that they have the same damage as is seen in pulmonary oxygen toxicity in the experimental animals. The symptoms of pulmonary oxygen poisoning begin slowly as a irritation that becomes progressively more intense and widespread along with increased coughing. Uncontrollable coughing occurs in severe cases, in addition to a burning sensation, which is worsened by inspiration.[2] There are many occurrences where oxygen intoxication is studied and tested on animals under non-standard physiological conditions to notice the effects of having an increased amount of oxygen [3] [4] [5]

## References

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1. ↑ http://www.wingoxybar.com.hk/effect/index_e.htm
2. ↑ 2.0 2.1 http://www.scuba-doc.com/pulo2tox.htm
3. ↑ R. ELSTON (1983) Histopathology of oxygen intoxication in the juvenile red abalone, Haliotis rufescens Swainson Journal of Fish Diseases 6 (2), 101–110. doi:10.1111/j.1365-2761.1983.tb00058.x.
4. ↑ Z. S. Gershenovich, A. A. Krichevskaya, J. Koloušek (1963) THE EFFECT OF RAISED OXYGEN PRESSURE AND OF METHIONINE SULPHOXIMINE ON THE GLUTAMINE SYNTHETASE ACTIVITY OF RAT BRAIN Journal of Neurochemistry 10 (2), 79–82.doi:10.1111/j.1471-4159.1963.tb11466.x
5. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6506586&dopt=Abstract

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