POEMS syndrome MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

## Overview

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MRI may be helpful in the diagnosis of POEMS syndrome. Findings on MRI suggestive of POEMS syndrome include diffuse lumbosacral nerve root enhancement on spinal imaging, bone lesions, hepatomegaly and splenomegaly on abdominal imaging, and on brain imaging, hyperintense lesions in the regions of periventricular and subcortical white matter and thalamus.

## MRI

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MRI may be helpful in the diagnosis of POEMS syndrome. Findings on MRI suggestive of POEMS syndrome include:

CNS

* Hyperintense lesions in the regions of periventricular and subcortical white matter and thalamus[1]
* Diffuse lumbosacral nerve root enhancement[2]

Musculoskeletal

* Bone lesions with low signal intensity[3]

Abdominal

* Hepatomegaly
* Splenomegaly

## Images

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MRI showing spinal nerve root enhancement. Source: Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID: 44859) MRI showing splenomegaly. Source: Case courtesy of Dr Michael Sargent, Radiopaedia.org, rID: 6002

## References

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1. ↑ Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK (April 2015). "POEMS syndrome with peripheral and central nervous system demyelination: case report". Neurologist. 19 (4): 101–3. doi:10.1097/NRL.0000000000000017. PMID 25888197.
2. ↑ Li Y, Valent J, Soltanzadeh P, Thakore N, Katirji B (July 2017). "Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series". J. Neurol. Sci. 378: 170–174. doi:10.1016/j.jns.2017.05.019. PMID 28566158.
3. ↑ Shi XF, Hu SD, Li JM, Luo XF, Long ZB, Zhu Y, Xi XD (2015). "Multimodal imaging and clinical characteristics of bone lesions in POEMS syndrome". Int J Clin Exp Med. 8 (5): 7467–76. PMC 4509235. PMID 26221290.

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