POLE2

VALUE_ERROR (nil)

Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

n/a

n/a

Ensembl| |

n/a

n/a

UniProt| |

n/a

n/a

RefSeq (mRNA)| |

n/a

n/a

RefSeq (protein)| |

n/a

n/a

Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
| View/Edit Human|

|

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.[1][2][3]

## Interactions

[edit | edit source]

POLE2 has been shown to interact with SAP18.[4]

## References

[edit | edit source]

1. ↑ Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem. 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.
2. ↑ Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res. 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964.
3. ↑ "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".
4. ↑ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

## Further reading

[edit | edit source]

* Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
* Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase ε". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
* Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
* Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.
* Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.

* v
* t
* e

DNA replication (comparing Prokaryotic to Eukaryotic)

Initiation|

| Prokaryotic
(initiation)|

* Pre-replication complex

* dnaC
* Cdc6

* Helicase
* dnaA
* dnaB
* T7

* Primase
* dnaG

|

Eukaryotic
(preparation in
G1 phase)|

* Pre-replication complex

* Origin recognition complex
* ORC1
* ORC2
* ORC3
* ORC4
* ORC5
* ORC6

* Cdc6

* Cdt1

* Minichromosome maintenance
* MCM2
* MCM3
* MCM4
* MCM5
* MCM6
* MCM7

* Licensing factor

* Autonomously replicating sequence

* Single-strand binding protein
* SSBP2
* SSBP3
* SSBP4

* RNase H
* RNASEH1
* RNASEH2A

* Helicase: HFM1

* Primase: PRIM1
* PRIM2

Both|

* Origin of replication/Ori/Replicon

* Replication fork
* Lagging and leading strands
* Okazaki fragments
* Primer

Replication|

| Prokaryotic
(elongation)|

* DNA polymerase III holoenzyme
* dnaC
* dnaE
* dnaH
* dnaN
* dnaQ
* dnaT
* dnaX
* holA
* holB
* holC
* holD
* holE
*   * Replisome
* DNA ligase
* DNA clamp
* Topoisomerase
* DNA gyrase

* Prokaryotic DNA polymerase: DNA polymerase I
* Klenow fragment

|

Eukaryotic
(synthesis in
S phase)|

* Replication factor C
* RFC1
* Flap endonuclease
* FEN1
* Topoisomerase
* Replication protein A
* RPA1

* Eukaryotic DNA polymerase:
* alpha
* POLA1
* POLA2
* PRIM1
* PRIM2
* delta
* POLD1
* POLD2
* POLD3
* POLD4
* epsilon
* POLE
* POLE2
* POLE3
* POLE4

* DNA clamp
* PCNA

* Control of chromosome duplication

Both|

* Movement: Processivity
* DNA ligase

Termination|

* Telomere: Telomerase
* TERT
* TERC
* DKC1

| This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

* v
* t
* e

|

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template