Pancreatic hormone

Pancreatic hormone peptide

Identifiers
Symbol| Hormone_3
Pfam| PF00159
InterPro| IPR001955
PROSITE| PDOC00238
SCOP| 1ppt
SUPERFAMILY| 1ppt
OPM protein| 1icy
| Available protein structures:

Pfam| structures
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pancreatic hormones (PP)[1] are peptides synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.

The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length[2] and has an amidated C terminus[3]. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,held close to the first helix by hydrophobic interactions[2]. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution[4]. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively[2].

## Subfamilies

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* Pancreatic hormone subtype InterPro: IPR015480
* Peptide YY InterPro: IPR015481

## Human proteins containing this domain

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NPY; PPY; PYY;

## References

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1. ↑ Humbel RE, Blundell TL (1980). "Hormone families: pancreatic hormones and homologous growth factors". Nature. 287 (5785): 781–787. doi:10.1038/287781a0. PMID 6107857. line feed character in `|title=` at position 18 (help)
2. ↑ 2.0 2.1 2.2 Martin J, Allen J, Novotny J, Heinrich G (1987). "Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2532–2536. doi:10.1073/pnas.84.8.2532. PMID 3031687.CS1 maint: Multiple names: authors list (link)
3. ↑ Mutt V, Sillard R, Agerberth B, Jornvall H (1989). "Sheep neuropeptide Y. A third structural type of a highly conserved peptide". FEBS Lett. 258 (2): 263–265. doi:10.1016/0014-5793(89)81669-2. PMID 2599092.CS1 maint: Multiple names: authors list (link)
4. ↑ Conlon JM, Thim L, Bjenning C, Moon TW, Youson JH (1991). "Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish". Peptides. 12 (2): 221–226. doi:10.1016/0196-9781(91)90003-8. PMID 2067973.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the public domain Pfam and InterPro: IPR001955

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