Phosphomevalonate kinase

Identifiers
EC number| 2.7.4.2
CAS number| 9026-46-4
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
| Search

PMC| articles
PubMed| articles
NCBI| proteins
Phosphomevalonate kinase

Identifiers
Symbol| PMVK
Entrez| 10654
HUGO| 9141
OMIM| 607622
RefSeq| NM_006556
UniProt| Q15126
Other data
EC number| 2.7.4.2
Locus| Chr. 1 p13-q23

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway.[1][2][3]

Mevalonate pathway

## References

[edit | edit source]

1. ↑ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234: 2595–604. PMID 13801508.
2. ↑ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
3. ↑ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75: 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

## External links

[edit | edit source]

* Phosphomevalonate+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)

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Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway|

| To HMG-CoA|

* Acetyl-Coenzyme A acetyltransferase
* HMG-CoA synthase (regulated step)

|

Ketogenesis|

* HMG-CoA lyase
* 3-hydroxybutyrate dehydrogenase
* Thiophorase

To Mevalonic acid|

* HMG-CoA reductase

To DMAPP|

* Mevalonate kinase
* Phosphomevalonate kinase
* Pyrophosphomevalonate decarboxylase
* Isopentenyl-diphosphate delta isomerase

Geranyl-|

* Dimethylallyltranstransferase
* Geranyl pyrophosphate

To cholesterol|

| To lanosterol|

* Farnesyl-diphosphate farnesyltransferase
* Squalene monooxygenase
* Lanosterol synthase

|

7-Dehydrocholesterol path|

* Lanosterol 14α-demethylase
* Sterol-C5-desaturase-like
* 7-Dehydrocholesterol reductase

Desmosterol path|

* 24-Dehydrocholesterol reductase

To Bile acids|

* Cholesterol 7α-hydroxylase
* Sterol 27-hydroxylase

Steroidogenesis|

| To pregnenolone|

* Cholesterol side-chain cleavage

|

To corticosteroids|

* aldosterone: 18-Hydroxylase

* cortisol/cortisone: 17α-Hydroxylase
* 11β-HSD
* 1
* 2

* both: 3β-HSD
* 1
* 2
* 21-Hydroxylase
* 11β-Hydroxylase

To sex hormones|

| To androgens|

* 17α-Hydroxylase
* 17,20-Lyase
* 3β-HSD
* 17β-HSD
* 5α-Reductase
* 1
* 2

|

To estrogens|

* Aromatase
* 17β-HSD

Other/ungrouped|

* Steroid metabolism: sulfatase
* Steroid sulfatase
* sulfotransferase
* SULT1A1
* SULT2A1

* Steroidogenic acute regulatory protein
* Cholesterol total synthesis
* Reverse cholesterol transport

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Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO4)|

| 2.7.1: OH acceptor|

* Hexo-
* Gluco-
* Fructo-
* Hepatic
* Galacto-
* Phosphofructo-
* 1
* Liver
* Muscle
* Platelet
* 2
* Riboflavin
* Shikimate
* Thymidine
* ADP-thymidine
* NAD+
* Glycerol
* Pantothenate
* Mevalonate
* Pyruvate
* Deoxycytidine
* PFP
* Diacylglycerol
* Phosphoinositide 3
* Class I PI 3
* Class II PI 3
* Sphingosine
* Glucose-1,6-bisphosphate synthase

|

2.7.2: COOH acceptor|

* Phosphoglycerate
* Aspartate kinase

2.7.3: N acceptor|

* Creatine

2.7.4: PO4 acceptor|

* Phosphomevalonate
* Adenylate
* Nucleoside-diphosphate
* Uridylate
* Guanylate
* Thiamine-diphosphate

2.7.6: diphosphotransferase
(P2O7)|

* Ribose-phosphate diphosphokinase
* Thiamine diphosphokinase

2.7.7: nucleotidyltransferase
(PO4-nucleoside)|

| Polymerase|

| DNA polymerase|

DNA-directed DNA polymerase

III

RNA-directed DNA polymerase
Reverse transcriptase

Telomerase

DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

|

RNA nucleotidyltransferase|

RNA polymerase/DNA-directed RNA polymerase
RNA polymerase I

III

Primase
RNA-dependent RNA polymerase

PNPase

Phosphorolytic
3' to 5' exoribonuclease|

* RNase PH
* PNPase

Nucleotidyltransferase|

* UTP—glucose-1-phosphate uridylyltransferase
* Galactose-1-phosphate uridylyltransferase

Guanylyltransferase|

* mRNA capping enzyme

Other|

* Recombinase (Integrase)
* Transposase

2.7.8: miscellaneous|

| Phosphatidyltransferases|

* CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
* CDP-diacylglycerol—serine O-phosphatidyltransferase
* CDP-diacylglycerol—inositol 3-phosphatidyltransferase
* CDP-diacylglycerol—choline O-phosphatidyltransferase

|

Glycosyl-1-phosphotransferase|

* N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)|

| 2.7.10: protein-tyrosine|

* see tyrosine kinases

|

2.7.11: protein-serine/threonine|

* see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity|

* see serine/threonine-specific protein kinases

2.7.13: protein-histidine|

* Protein-histidine pros-kinase
* Protein-histidine tele-kinase
* Histidine kinase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)

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*[HSD]: Hydroxysteroid dehydrogenase