Premature ovarian failure

Premature ovarian failure Microchapters

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Overview

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Pathophysiology

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Differentiating Premature ovarian failure from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

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Physical Examination

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Premature ovarian failure

ICD-10 | E28.3
ICD-9 | 256.31
DiseasesDB | 9441
MeSH | D016649

## Overview

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## Historical Perspective

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## Classification

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## Pathophysiology

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## Differentiating Premature ovarian failure from other Diseases

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## Epidemiology and Demographics

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## Risk Factors

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## Screening

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## Natural History, Complications and Prognosis

[edit | edit source]

## Diagnosis

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History and Symptoms  | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

## Treatment

[edit | edit source]

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

## Case Studies

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Case #1

## Related Chapters

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Impaired Ovarian Reserve

Premature Menopause

## External links

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U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NICHD Information Resource Center, Do I have Premature Ovarian Failure? NIH pub. No. 03-5159, August 2003. You can order free copies by calling 1-800-370-2943, and it’s also available for download at http://www.nichd.nih.gov/publications/pubs/pof/upload/premature_ovarian_failure.pdf

National Institutes of Health/ Premature Ovarian Failure website http://eclipse.nichd.nih.gov/nichd/deb/geuPOF/resources.htm

Current POF Clinical trials via the NIH recruiting patients http://www.clinicaltrials.gov and search “premature ovarian failure”

"What's The Best Approach To Spontaneous Premature Ovarian Failure?", by Dr. Lawrence Nelson, Principal Investigator at NIH for POF research studies/clinical trials. http://pof.nichd.nih.gov/Contemp_ObGyn_2004_POF.pdf

Women with premature menopause at increased risk for potentially fatal adrenal condition-early diagnosis can lead to effective treatment, NIH News Release. http://www.nih.gov/news/pr/aug2002/nichd-30.htm. Nelson, L., 2002.

Irregular periods in young women could be warning sign for later osteoporosis, NIH News Release. http://www.nih.gov/news/pr/may2002/nichd-29.htm. Nelson, L., 2002.

## References

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Endocrine pathology: endocrine diseases (E00-35, 240-259)

Thyroid|

Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) - Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) - Euthyroid sick syndrome

Pancreas|

Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Hypoglycemia \- Hyperinsulinism \- Zollinger-Ellison syndrome \- insulin receptor (Rabson-Mendenhall syndrome)

Parathyroid|

Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary)

Pituitary|

Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) - Hypopituitarism (Simmonds' disease / Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) - Adiposogenital dystrophy \- Empty sella syndrome \- Hypophysitis

Adrenal|

Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - CAH (Lipoid, 3β, 11β, 17α, 21α) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism

Gonads|

Ovarian dysfunction (Polycystic ovary syndrome, Premature ovarian failure) - Testicular dysfunction (5-alpha-reductase deficiency) - Testosterone biosynthesis (17-beta-hydroxysteroid dehydrogenase deficiency) - General (Hypogonadism, Delayed puberty, Precocious puberty)

Other|

Androgen insensitivity syndrome \- Autoimmune polyendocrine syndrome \- Carcinoid syndrome \- Gigantism \- Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria \- Woodhouse-Sakati syndrome

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