Procollagen peptidase

procollagen (type III) N-endopeptidase

Identifiers
Symbol| PCOLN3
Alt. symbols| PRSM1
Entrez| 5119
HUGO| 8740
OMIM| 164010
RefSeq| NM_002768
UniProt| Q9HD42
Other data
EC number| 3.4.24.14
Locus| Chr. 16 q24.3

Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]

The enzyme is present in the skin of rats and humans.[2]

## External links[edit | edit source]

* The MEROPS online database for peptidases and their inhibitors: Procollagen C-Peptidase:M12.005, Procollagen N-Peptidase:M12.301

## References[edit | edit source]

1. ↑ http://www.biology-online.org/dictionary/Procollagen_peptidase
2. ↑ Lapière CM, Lenaers A, Kohn LD (December 1971). "Procollagen peptidase: an enzyme excising the coordination peptides of procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–8. doi:10.1073/pnas.68.12.3054. PMC 389589. PMID 5289249.

## External links[edit | edit source]

* Procollagen+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

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Protein: scleroproteins

Extracellular matrix|

| Collagen|

| Fibril forming|

* type I
* COL1A1
* COL1A2
* type II (COL2A1)
* type III
* type V
* COL5A1
* COL5A2
* COL5A3
* COL24A1
* COL26A1

|

Other|

* FACIT: type IX
* COL9A1
* COL9A2
* COL9A3
* type XII (COL12A1)
* COL14A1
* COL16A1
* COL19A1
* COL20A1
* COL21A1
* COL22A1

* basement membrane: type IV
* COL4A1
* COL4A2
* COL4A3
* COL4A4
* COL4A5
* COL4A6

* multiplexin: COL15A1
* type XVIII
* COL18A1
* Endostatin

* transmembrane: COL13A1
* COL17A1
* COL23A1
* COL25A1

* other: type VI
* COL6A1
* COL6A2
* COL6A3
* COL6A5
* type VII (COL7A1)
* type VIII
* COL8A1
* COL8A2
* type X (COL10A1)
* type XI
* COL11A1
* COL11A2
* COL27A1
* COL28A1

Enzymes|

* Prolyl hydroxylase/Lysyl hydroxylase
* Cartilage associated protein/Leprecan
* ADAMTS2
* Procollagen peptidase
* Lysyl oxidase

Laminin|

* alpha
* LAMA1
* LAMA2
* LAMA3
* LAMA4
* LAMA5
* beta
* LAMB1
* LAMB2
* LAMB3
* LAMB4
* gamma
* LAMC1
* LAMC2
* LAMC3

Other|

* ALCAM
* Elastin
* Tropoelastin
* Vitronectin
* FRAS1
* FREM2
* Decorin
* FAM20C
* ECM1
* Matrix gla protein
* Tectorin
* TECTA
* TECTB

Other|

* Keratin/Cytokeratin
* Gelatin
* Reticulin
* Cartilage oligomeric matrix protein

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Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins|

* Alpha secretases
* ADAM9
* ADAM10
* ADAM17
* ADAM19
* ADAM2
* ADAM7
* ADAM8
* ADAM11
* ADAM12
* ADAM15
* ADAM18
* ADAM22
* ADAM23
* ADAM28
* ADAM33
* ADAMTS1
* ADAMTS2
* ADAMTS3
* ADAMTS4
* ADAMTS5
* ADAMTS8
* ADAMTS9
* ADAMTS10
* ADAMTS12
* ADAMTS13

Matrix metalloproteinases|

* Collagenases
* MMP1
* MMP8
* Gelatinases
* MMP2
* MMP9
* MMP3
* MMP7
* MMP10
* MMP11
* MMP12
* MMP13
* MMP14
* MMP15
* MMP16
* MMP17
* MMP19
* MMP20
* MMP21
* MMP23A
* MMP23B
* MMP24
* MMP25
* MMP26
* MMP27
* MMP28

Other|

* Neprilysin
* Procollagen peptidase
* Thermolysin
* Pregnancy-associated plasma protein A
* Bone morphogenetic protein 1
* Lysostaphin
* Insulin-degrading enzyme
* ZMPSTE24

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)

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