Pyrophosphomevalonate decarboxylase

Mevalonate (diphospho) decarboxylase

Identifiers
Symbol| MVD
Entrez| 4597
HUGO| 7529
OMIM| 603236
RefSeq| NM_002461
UniProt| P53602
Other data
EC number| 4.1.1.33
Locus| Chr. 16 q24.3

Pyrophosphomevalonate decarboxylase (or mevalonate-5-pyrophosphate decarboxylase) is an enzyme in the mevalonate pathway.

Mevalonate pathway

## External links

[edit | edit source]

* Pyrophosphomevalonate+decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)

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Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases|

* Acetoacetate decarboxylase
* Adenosylmethionine decarboxylase
* Arginine decarboxylase
* Aromatic L-amino acid decarboxylase
* Glutamate decarboxylase
* Histidine decarboxylase
* Lysine decarboxylase
* Malonyl-CoA decarboxylase
* Ornithine decarboxylase
* Oxaloacetate decarboxylase
* Phosphoenolpyruvate carboxykinase
* Phosphoenolpyruvate carboxylase
* Phosphoribosylaminoimidazole carboxylase
* Pyrophosphomevalonate decarboxylase
* Pyruvate decarboxylase
* RuBisCO
* Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase
* Uroporphyrinogen III decarboxylase

4.1.2: Aldehyde-lyases|

* Fructose-bisphosphate aldolase
* Aldolase A
* Aldolase B
* Aldolase C
* 2-hydroxyphytanoyl-CoA lyase
* Threonine aldolase

4.1.3: Oxo-acid-lyases|

* Isocitrate lyase
* 3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other|

* Tryptophanase
* Photolyase
* CPD lyase
* Spore photoproduct lyase

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Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway|

| To HMG-CoA|

* Acetyl-Coenzyme A acetyltransferase
* HMG-CoA synthase (regulated step)

|

Ketogenesis|

* HMG-CoA lyase
* 3-hydroxybutyrate dehydrogenase
* Thiophorase

To Mevalonic acid|

* HMG-CoA reductase

To DMAPP|

* Mevalonate kinase
* Phosphomevalonate kinase
* Pyrophosphomevalonate decarboxylase
* Isopentenyl-diphosphate delta isomerase

Geranyl-|

* Dimethylallyltranstransferase
* Geranyl pyrophosphate

To cholesterol|

| To lanosterol|

* Farnesyl-diphosphate farnesyltransferase
* Squalene monooxygenase
* Lanosterol synthase

|

7-Dehydrocholesterol path|

* Lanosterol 14α-demethylase
* Sterol-C5-desaturase-like
* 7-Dehydrocholesterol reductase

Desmosterol path|

* 24-Dehydrocholesterol reductase

To Bile acids|

* Cholesterol 7α-hydroxylase
* Sterol 27-hydroxylase

Steroidogenesis|

| To pregnenolone|

* Cholesterol side-chain cleavage

|

To corticosteroids|

* aldosterone: 18-Hydroxylase

* cortisol/cortisone: 17α-Hydroxylase
* 11β-HSD
* 1
* 2

* both: 3β-HSD
* 1
* 2
* 21-Hydroxylase
* 11β-Hydroxylase

To sex hormones|

| To androgens|

* 17α-Hydroxylase
* 17,20-Lyase
* 3β-HSD
* 17β-HSD
* 5α-Reductase
* 1
* 2

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To estrogens|

* Aromatase
* 17β-HSD

Other/ungrouped|

* Steroid metabolism: sulfatase
* Steroid sulfatase
* sulfotransferase
* SULT1A1
* SULT2A1

* Steroidogenic acute regulatory protein
* Cholesterol total synthesis
* Reverse cholesterol transport

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*[HSD]: Hydroxysteroid dehydrogenase