Quinine Sulfate dosage and administration

Quinine Sulfate

QUALAQUIN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Chetan Lokhande, M.B.B.S [2]

## Dosage And Administration[edit | edit source]

### Treatment of Uncomplicated P. falciparum Malaria[edit | edit source]

For treatment of uncomplicated P. falciparum malaria in adults: Orally, 648 mg (two capsules) every 8 hours for 7 days.

QUALAQUIN should be taken with food to minimize gastric upset [see Clinical Pharmacology].

### Renal Impairment[edit | edit source]

In patients with acute uncomplicated malaria and severe chronic renal impairment, the following dosage regimen is recommended: one loading dose of 648 mg QUALAQUIN followed 12 hours later by maintenance doses of 324 mg every 12 hours.

The effects of mild and moderate renal impairment on the safety and pharmacokinetics of quinine sulfate are not known [see Clinical Pharmacology].

### Hepatic Impairment[edit | edit source]

Adjustment of the recommended dose is not required in mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment, but patients should be monitored closely for adverse effects of quinine. Quinine should not be administered in patients with severe (Child-Pugh C) hepatic impairment [see Clinical Pharmacology].[1]

## References[edit | edit source]

1. ↑ "QUALAQUIN (QUININE SULFATE) CAPSULE [AR SCIENTIFIC INC.]".

Adapted from the FDA Package Insert.