Rigor

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Shaking chills

## Overview

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Rigor is a shaking occurring during a high fever. It occurs because cytokines and prostaglandins are released as part of an immune response and increase the set point for body temperature in the hypothalamus.

The increased set point causes the body temperature to rise (pyrexia), but also makes the patient feel cold until the new set point is reached. Rigor occurs because the patient is effectively shivering in a physiological attempt to increase body temperature to the new set point.

## Causes

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### Common Causes

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* Acute cholangitis
* Amphotericin B
* Anti-TNF alpha drugs
* Biliary sepsis
* Brucellosis
* Catheterization
* Dressler's syndrome
* Filariasis
* Gastroenteritis
* Generalized pustular psoriasis
* Gentamicin
* Hemodialysis
* Infective endocarditis
* Influenza
* Interleukin II
* Jarisch-Herxheimer reaction
* Lemierre's syndrome
* Louse-borne relapsing fever
* Lyme disease
* Malaria
* Meningitis

* Meningococcal septicemia
* Normal vaginal delvery
* Pericarditis
* Pneumonia
* Post bone marrow transplant
* Post operative infections
* Post radiotherapy
* Prostate cancer
* Prostatitis
* Pyelonephritis
* Rat bite fever
* Rheumatic fever
* Septic arthritis
* Sepsis
* Severe acute respiratory syndrome
* Severe generalized rash
* Transfusion reaction
* Tonsillitis
* Tuberculosis
* Ulcerative colitis
* Urinary tract infections
* Vancomycin
* Visceral abscess

|

### Causes by Organ System

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Cardiovascular | No underlying causes

|

Chemical / poisoning | No underlying causes
Dermatologic | No underlying causes
Drug Side Effect | Agalsidase beta, Denileukin diftitox, Doxorubicin Hydrochloride, Imiglucerase, Ixabepilone, Meropenem, Panitumumab, Pergolide, Pramipexole, Ramucirumab, Sargramostim, Sipuleucel-T, Teniposide, Tiagabine, Voriconazole, Zanamivir
Ear Nose Throat | No underlying causes
Endocrine | No underlying causes
Environmental | No underlying causes
Gastroenterologic | No underlying causes
Genetic | No underlying causes
Hematologic | No underlying causes
Iatrogenic | No underlying causes
Infectious Disease | No underlying causes
Musculoskeletal / Ortho | No underlying causes
Neurologic | No underlying causes
Nutritional / Metabolic | No underlying causes
Obstetric/Gynecologic | No underlying causes
Oncologic | No underlying causes
Opthalmologic | No underlying causes
Overdose / Toxicity | No underlying causes
Psychiatric | No underlying causes
Pulmonary | No underlying causes
Renal / Electrolyte | No underlying causes
Rheum / Immune / Allergy | No underlying causes
Sexual | No underlying causes
Trauma | No underlying causes
Urologic | No underlying causes
Dental | No underlying causes
Miscellaneous | No underlying causes

### Causes in Alphabetical Order

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* Doxorubicin Hydrochloride
* Ixabepilone
* Panitumumab
* Pergolide
* Ramucirumab
* Sargramostim
* Sipuleucel-T
* Teniposide
* Tiagabine
* Voriconazole

## Related Chapters

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* Rigor mortis

## References

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