SAE2

SUMO1 activating enzyme subunit 2

File:PBB Protein SAE2 image.jpg

PDB rendering based on 1y8q.

| Available structures

PDB |  Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
| List of PDB id codes

1y8q​, 1y8r​

Identifiers
Symbols|  SAE2 ; FLJ13058; HRIHFB2115; UBA2
External IDs|  Template:MGI HomoloGene: 4018
| Gene ontology

Molecular function | Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Cellular component | Template:GNF GO
Biological process | Template:GNF GO
RNA expression pattern
File:PBB GE SAE2 201177 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

SUMO1 activating enzyme subunit 2, also known as SAE2, is a human gene.[1]

## References

[edit | edit source]

1. ↑ "Entrez Gene: SAE2 SUMO1 activating enzyme subunit 2".

## Further reading

[edit | edit source]

* Ueki N, Oda T, Kondo M; et al. (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Okuma T, Honda R, Ichikawa G; et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Desterro JM, Rodriguez MS, Kemp GD, Hay RT (1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. PMID 10187858.CS1 maint: Multiple names: authors list (link)
* Gong L, Li B, Millas S, Yeh ET (1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. PMID 10217437.CS1 maint: Multiple names: authors list (link)
* Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Tatham MH, Jaffray E, Vaughan OA; et al. (2001). "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9". J. Biol. Chem. 276 (38): 35368–74. doi:10.1074/jbc.M104214200. PMID 11451954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Azuma Y, Tan SH, Cavenagh MM; et al. (2001). "Expression and regulation of the mammalian SUMO-1 E1 enzyme". FASEB J. 15 (10): 1825–7. PMID 11481243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Tatham MH, Kim S, Yu B; et al. (2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry. 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Boggio R, Colombo R, Hay RT; et al. (2005). "A mechanism for inhibiting the SUMO pathway". Mol. Cell. 16 (4): 549–61. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lois LM, Lima CD (2005). "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1". EMBO J. 24 (3): 439–51. doi:10.1038/sj.emboj.7600552. PMID 15660128.
* Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Bossis G, Melchior F (2006). "Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes". Mol. Cell. 21 (3): 349–57. doi:10.1016/j.molcel.2005.12.019. PMID 16455490.
* Li T, Santockyte R, Shen RF; et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers". Arch. Biochem. Biophys. 453 (1): 70–4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lemos TA, Kobarg J (2006). "CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus". Cell Biochem. Biophys. 44 (3): 463–74. PMID 16679534.
* Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

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