Seborrheic keratosis

Seborrheic Keratosis: Gross natural color photo of face with multiple typical lesions. Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10 | L82
ICD-9 | 702.1
OMIM | 182000
DiseasesDB | 29386
eMedicine | derm/397
MeSH | D017492

Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

A seborrheic keratosis is a benign skin growth that is very common among people over 40 years of age.

## Presentation[edit | edit source]

The growths resemble flattened or raised warts, but have no viral origins and may exhibit a variety of colors, from pink or yellow through brown and black. Because only the top layers of the epidermis are involved, seborrheic keratoses are often described as having a "pasted-on" appearance.

## Treatment[edit | edit source]

Because the tumors are rarely painful, treatment is not often necessary. There is a small risk of localized infection caused by picking at the lesion. If a growth becomes excessively itchy, or if it is irritated by clothing or jewelry, cryosurgery has been found to be highly effective in their removal. The main danger associated with seborrheic keratoses lies in their resemblance to malignant melanomas, which has sometimes led to a misdiagnosis of the cancerous lesions. If there is any doubt, a skin biopsy will allow a physician to make a correct diagnosis.

## Causes[edit | edit source]

A mutation of a gene coding for a growth factor receptor (FGFR3), has been associated with seborrheic keratosis.[1]

## References[edit | edit source]

1. ↑ Hafner C, Hartmann A, Vogt T (2007). "FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin". J. Invest. Dermatol. 127 (7): 1572–3. doi:10.1038/sj.jid.5700772. PMID 17568799.CS1 maint: Multiple names: authors list (link)

## External links[edit | edit source]

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Diseases of the skin and subcutaneous tissue (integumentary system) (L, 680-709)

Infections|

Template:Navbox subgroup

Bullous disorders|

acantholysis (Pemphigus, Transient acantholytic dermatosis) * Pemphigoid (Bullous, Cicatricial, Gestational) * Dermatitis herpetiformis

Inflammatory|

Template:Navbox subgroup

Radiation-related disorders|

Sunburn * actinic rays (Actinic keratosis, Actinic cheilitis) * Polymorphous light eruption (Acne aestivalis) * Radiodermatitis * Erythema ab igne

Pigmentation disorder|

hypopigmentation (Albinism, Vitiligo) * hyperpigmentation (Melasma, Freckle, Café au lait spot, Lentigo/Liver spot, Acanthosis nigricans, Acral acanthotic anomaly)

Other skin|

keratosis/hyperkeratosis (Seborrheic keratosis, Callus) * other epidermal thickening (Ichthyosis acquisita, Palmoplantar keratoderma)

skin ulcer (Pyoderma gangrenosum, Bedsore)

Cutaneous Markers of Internal Malignancy (Florid cutaneous papillomatosis, acanthosis nigricans, sign of Leser-Trelat)

atrophic (Lichen sclerosus, Acrodermatitis chronica atrophicans)

necrobiosis (Granuloma annulare, Necrobiosis lipoidica) * other granuloma (Granuloma faciale, Pyogenic granuloma)

cutaneous vasculitis (Livedoid vasculitis, Erythema elevatum diutinum)

Connective tissues|

collagen disease: Keloid
localized connective tissue disorders: Lupus erythematosus (Discoid lupus erythematosus, Subacute cutaneous lupus erythematosus) * Scleroderma/Morphea * Linear scleroderma * Calcinosis cutis * Sclerodactyly * Ainhum

see also congenital, neoplasia

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