Signaling lymphocytic activation molecule

Identifiers
Symbol| SLAM
Pfam| PF06214
InterPro| IPR010407
Membranome| 164
| Available protein structures:

Pfam| structures
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion [1][2]

Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.

A defective SLAM associated protein (SAP) causes X-linked lymphoproliferative syndrome (XLP), a frequently lethal mononucleosis based on the inability to control EBV

Members of the family include:

* SLAMF1 (CD150)
* SLAMF2 (CD48)[3]
* SLAMF3 (CD229, LY9)
* SLAMF4 (CD244)
* SLAMF5 (CD84)
* SLAMF6 (CD352)[4]
* SLAMF7 (CD319)[5]
* SLAMF8 (CD353)[6]
* SLAMF9[7]

## References

[edit | edit source]

1. ↑ "SLAM FAMILY, MEMBER 1". OMIM. Retrieved 19 March 2014.
2. ↑ Rosenbach T, Csatò M, Czarnetzki BM (January 1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. doi:10.1111/j.1365-2133.1988.tb01743.x. PMID 2829957.
3. ↑ Sintes J, Engel P (February 2011). "SLAM (CD150) is a multitasking immunoreceptor: from cosignalling to bacterial recognition". Immunology and Cell Biology. 89 (2): 161–3. doi:10.1038/icb.2010.145. PMID 21102539.
4. ↑ Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC (May 2011). "SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells". Autoimmunity. 44 (3): 211–8. doi:10.3109/08916934.2010.530627. PMC 4465387. PMID 21231893.
5. ↑ Kim JR, Horton NC, Mathew SO, Mathew PA (August 2013). "CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes". Inflammation Research. 62 (8): 765–72. doi:10.1007/s00011-013-0632-1. PMID 23695528.
6. ↑ Wang G, Abadía-Molina AC, Berger SB, Romero X, O'Keeffe MS, Rojas-Barros DI, Aleman M, Liao G, Maganto-García E, Fresno M, Wang N, Detre C, Terhorst C (June 2012). "Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages". Journal of Immunology. 188 (12): 5829–32. doi:10.4049/jimmunol.1102620. PMC 3370125. PMID 22593622.
7. ↑ Pott S, Kamrani NK, Bourque G, Pettersson S, Liu ET (2012). Jothi R, ed. "PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse". PLOS One. 7 (10): e48102. doi:10.1371/journal.pone.0048102. PMC 3485280. PMID 23118933.

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