Spina bifida diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Mohamadmostafa Jahansouz M.D.[2]

## Overview

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Ultrasound is the imaging modality of choice for characterisation of the open spina bifida spinal lesions. On two and tree-dimensional ultrasound, spina bifida is characterized by: Vertebral defect, splayed vertebral pedicles and disrupted vertebrae. The ultrasound must be performed when a positive alpha-fetoprotein is detected in the triple screening test between the 15th and 20th week of pregnancy to confirm the diagnosis.

## Diagnostic Study of Choice

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### Study of choice

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* Ultrasound is the imaging modality of choice for characterisation of the open spina bifida spinal lesions.[1]
* On two and tree-dimensional ultrasound, spina bifida is characterized by:[2]
* Vertebral defect
* Splayed vertebral pedicles
* Disrupted vertebrae

##### Sequence of Diagnostic Studies

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The ultrasound must be performed when a positive alpha-fetoprotein is detected in the triple screening test between the 15th and 20th week of pregnancy to confirm the diagnosis.[3][4][5][6]

## References

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1. ↑ Trudell AS, Odibo AO (April 2014). "Diagnosis of spina bifida on ultrasound: always termination?". Best Pract Res Clin Obstet Gynaecol. 28 (3): 367–77. doi:10.1016/j.bpobgyn.2013.10.006. PMID 24373566.
2. ↑ Lee W, Chaiworapongsa T, Romero R, Williams R, McNie B, Johnson A, Treadwell M, Comstock CH (June 2002). "A diagnostic approach for the evaluation of spina bifida by three-dimensional ultrasonography". J Ultrasound Med. 21 (6): 619–26. PMID 12054297.
3. ↑ Péron FG, McCarthy JL, Guerra F (April 1966). "Further studies on corticosteroidogenesis. IV. Inhibition of utilization of biological substrates for corticoid synthesis by high calcium concentrations. Possible role of transhydrogenase in corticosteroidogenesis". Biochim. Biophys. Acta. 117 (2): 450–69. PMID 4381295.
4. ↑ Hu Z, Liu X, Li L, Jia C, Li D, Liu R (October 2014). "[Predictive value of abnormal second-trimester maternal serum triple screening markers for adverse pregnancy outcomes]". Zhonghua Fu Chan Ke Za Zhi (in Chinese). 49 (10): 749–53. PMID 25537246.CS1 maint: Unrecognized language (link)
5. ↑ Wyshak G, Haase JV (November 1976). "Profile of dental hygienists". Dent Hyg (Chic). 50 (11): 497–501. PMID 1071059.
6. ↑ Shcherbukhin VV, Khramtsov AV, Zemskov VM, Filatov AV (April 1987). "[Poisson equalization of multicomponent cytofluorograms]". Tsitologiia (in Russian). 29 (4): 497–502. PMID 3111043.CS1 maint: Unrecognized language (link)

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