Synovial sarcoma overview

Synovial sarcoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Synovial sarcoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Immunohistochemical Techniques

Chest X Ray

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Synovial sarcoma overview On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Synovial sarcoma overview

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Synovial sarcoma overview

CDC on Synovial sarcoma overview

Synovial sarcoma overview in the news

Blogs on Synovial sarcoma overview

Directions to Hospitals Treating Synovial sarcoma

Risk calculators and risk factors for Synovial sarcoma overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview[edit | edit source]

Synovial sarcoma is a rare soft-tissue sarcoma defined by the presence of a unique translocation, t(X;18)(q11.2;p11.2). It usually occurs adjacent to joints in the limbs and was originally thought to arise from synovium.

However, synovial sarcoma is a misnomer and the origin of the tissue is unknown. Primary synovial sarcomas have been documented in most human tissues and organs, including the brain, prostate and heart. Synovial sarcoma occurs most commonly in adolescents and young adults. Diagnosis is based on histology; there are three major histologic subtypes: monophasic (consisting on sheets of spindle cells), biphasic (spindle cells admixed with areas of epithelial differentiation) and poorly differentiated. Immunohistochemical techniques can help, however the gold standard for diagnosing synovial sarcoma is detection of t(X;18) by cytogenetics, FISH or RT-PCR. Despite treatment, prognosis is generally poor, with approximately 50% of patients dying from local reccurrence or metastasis within 10 years.

## References[edit | edit source]

Template:WH Template:WS Category:Disease