Syphilis dark field microscopy

* Dark field microscopy may be performed in cases wherein serologic tests do not correspond with clinical findings suggestive of early syphilis.

* It may also be helpful in the evaluation of cutaneous lesions such as chancre or condylomata lata.

* Direct fluorescent antibody (DFA-TP) assay of fixed smears may be indicated if dark field microscopy is not available.

* Dark field microscopy and DFA-TP assay have a specificity rate of 85-92%

## Resources

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* Sexually transmitted diseases treatment guidelines, 2010[1]

* Association of Public Health Laboratories (APHL). Laboratory Diagnostic Testing for Treponema pallidum. Expert Consultation Meeting Summary Report, January 13--15, 2009, Atlanta, GA

* CDC: Guidelines for the laboratory diagnosis of gonorrhea, chlamydia and syphilis

## References

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1. ↑ Workowski KA, Berman S (2010). "Sexually transmitted diseases treatment guidelines, 2010". MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports / Centers for Disease Control. 59 (RR-12): 1–110. PMID 21160459. Retrieved 2012-02-16. Unknown parameter `|month=` ignored (help)

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