TGF beta receptor

transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa)

Identifiers
Symbol| TGFBR1
Alt. symbols| ALK5
Entrez| 7046
HUGO| 11772
OMIM| 190181
RefSeq| NM_004612
UniProt| P36897
Other data
Locus| Chr. 9 q22
transforming growth factor beta, receptor type II (70/80kDa)

Identifiers
Symbol| TGFBR2
Alt. symbols| MFS2
Entrez| 7048
HUGO| 11773
OMIM| 190182
RefSeq| NM_001024847
UniProt| P37173
Other data
Locus| Chr. 3 p22
transforming growth factor beta, receptor type III

Identifiers
Symbol| TGFBR3
Alt. symbols| β-Glycan
Entrez| 7049
HUGO| 11774
OMIM| 600742
RefSeq| NM_003243
UniProt| Q03167
Other data
Locus| Chr. 1 p33-p32

Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in several different isoforms that can be homo\- or heterodimeric.[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.

TGFβ is a growth factor and cytokine involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, bone, and testes. Over-expression of TGFβ can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease. Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.

Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties. TGFβR1 (ALK5) and TGFβR2 have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both TGFβR1 and TGFβR2 have a high affinity for TGFβ1 and low affinity for TGFβ2. TGFβR3 (β-glycan) has a high affinity for both homodimeric TGFβ1 and TGFβ2 and in addition the heterodimer TGF-β1.2.[2] The TGFβ receptors also bind TGFβ3.

## See also

[edit | edit source]

* TGFβ superfamily receptor
* TGFβ signaling pathway
* TGFβ superfamily

## References

[edit | edit source]

1. ↑ Doré JJ, Edens M, Garamszegi N, Leof EB (November 1998). "Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells". The Journal of Biological Chemistry. 273 (48): 31770–7. doi:10.1074/jbc.273.48.31770. PMID 9822641. (free full text)
2. ↑ Cheifetz S, Andres JL, Massagué J (November 1988). "The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor". The Journal of Biological Chemistry. 263 (32): 16984–91. PMID 2903157.

## External links

[edit | edit source]

* TGF-beta+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Cell signaling: TGFβ signaling pathway

TGF beta superfamily of ligands|

| TGF beta family|

* TGF-β1
* TGF-β2
* TGF-β3

|

Bone morphogenetic proteins|

* BMP2
* BMP3
* BMP4
* BMP5
* BMP6
* BMP7
* BMP8a
* BMP8b
* BMP10
* BMP15

Growth differentiation factors|

* GDF1
* GDF2
* GDF3
* GDF5
* GDF6
* GDF7
* Myostatin/GDF8
* GDF9
* GDF10
* GDF11
* GDF15

Other|

* Activin and inhibin
* Anti-müllerian hormone
* Nodal

TGF beta receptors
(Activin, BMP)|

| TGFBR1:|

* Activin type 1 receptors
* ACVR1
* ACVR1B
* ACVR1C
* ACVRL1
* BMPR1
* BMPR1A
* BMPR1B

|

TGFBR2:|

* Activin type 2 receptors
* ACVR2A
* ACVR2B
* AMHR2
* BMPR2

TGFBR3:|

* betaglycan

Transducers/SMAD|

* R-SMAD (SMAD1
* SMAD2
* SMAD3
* SMAD5
* SMAD9)
* I-SMAD (SMAD6
* SMAD7)
* SMAD4

Ligand inhibitors|

* Cerberus
* Chordin
* Decorin
* Follistatin
* Gremlin
* Lefty
* LTBP1
* Noggin
* PARN
* THBS1

Coreceptors|

* BAMBI
* Cripto

Other|

* SARA

* v
* t
* e

Receptors: growth factor receptors

Type I cytokine receptor|

* Nerve growth factors: Ciliary neurotrophic factor
* Erythropoietin

Receptor protein serine/threonine kinase|

* TGF pathway: TGF-beta
* 1
* 2
* Activin
* 1
* 2
* Bone morphogenetic protein
* 1
* 2

Receptor tyrosine kinase|

* Fibroblast growth factor
* 1
* 2
* 3
* 4

* Nerve growth factors: high affinity Trk
* TrkA
* TrkB
* TrkC

* Hepatocyte growth factor

* Somatomedin
* Insulin-like growth factor 1

* ErbB/Epidermal growth factor

* VEGF
* 1
* 2
* 3

Tumor necrosis factor receptor|

* Nerve growth factors: Low affinity/p75

Ig superfamily|

* Platelet-derived growth factor
* A
* B
* Stem cell factor

Other/ungrouped|

* Somatomedin
* Insulin-like growth factor 2

* v
* t
* e

Cytokine receptors

Chemokine receptor
(GPCRs)|

| CC|

* CCR1 / CCRL1
* CCR2
* CCRL2
* CCR3
* CCR4
* CCR5
* CCR6
* CCR7
* CCR8
* CCR9
* CCR10

|

CXC|

* IL-8
* CXCR1
* CXCR2
* CXCR3
* CXCR4
* CXCR5
* CXCR6
* CXCR7

Other|

* CX3C
* CX3CR1
* XC
* XCR1
* CCBP2
* CMKLR1

TNF receptor|

| 1-10|

* TNFR1 (TNFRSF1A)
* TNFR2 (TNFRSF1B)
* LTBR (TNFRSF3)
* CD134 (TNFRSF4)
* CD40 (TNFRSF5)
* Fas receptor (TNFRSF6)
* DcR3 (TNFRSF6B)
* CD27 (TNFRSF7)
* CD30 (TNFRSF8)
* CD137 (TNFRSF9)

|

11-20|

* DR4 (TNFRSF10A)
* DR5 (TNFRSF10B)
* DcR1 (TNFRSF10C)
* DcR2 (TNFRSF10D)
* RANK (TNFRSF11A)
* Osteoprotegerin (TNFRSF11B)
* TweakR (TNFRSF12A)
* TACI (TNFRSF13B)
* BAFFR (TNFRSF13C)
* HVEM (TNFRSF14)
* NGFR (TNFRSF16)
* BCMA (TNFRSF17)
* GITR (TNFRSF18)
* TAJ/TROY (TNFRSF19)

21-27|

* DR6 (TNFRSF21)
* DR3 (TNFRSF25)
* EDA2R (TNFRSF27)

JAK-STAT|

| Type I|

| γ-chain|

* Interleukin receptors
* IL2R / IL2RA/IL2RB / IL15R
* IL4R / IL13R / IL13RA1 / IL13RA2
* IL7R / IL7RA
* IL9R
* IL21R

|

β-chain|

* Interleukin receptors
* IL3R / IL3RA
* IL5R / IL5RA
* GM-CSF

gp130|

* Interleukin receptors
* IL6RA
* 11/IL11RA
* 27/IL27RA
* OSMR
* LIFR
* CNTFR

IL12RB1|

* Interleukin receptors
* IL12R/IL12RB1/IL12RB2
* IL23R23

Other|

* other CSF receptors
* EPO
* G-CSF
* Thrombopoietin

* hormone receptor: GH
* prolactin

Type II|

* Interleukin receptors
* IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
* IL20R / IL20RA / IL20RB
* IL28R
* Interferon receptors
* -α/β / IFNAR1/IFNAR2
* -γ/IFNGR1 / IFNGR2

Ig superfamily|

* CSF1
* KIT
* IL1
* IL1R1
* IL1R2
* IL18R / IL18R1

IL 17 family|

* IL17
* IL17RA
* IL17RB
* IL17RC
* IL17RD
* IL17RE

S/T|

* TGF-beta
* TGFBR1
* TGFBR2

* v
* t
* e

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

| Non-specific serine/threonine protein kinases (EC 2.7.11.1)|

* LATS1
* LATS2
* MAST1
* MAST2
* STK38
* STK38L
* CIT
* ROCK1
* SGK
* SGK2
* SGK3
* Protein kinase B
* AKT1
* AKT2
* AKT3
* Ataxia telangiectasia mutated
* mTOR
* EIF-2 kinases
* PKR
* HRI
* EIF2AK3
* EIF2AK4
* Wee1
* WEE1

|

Pyruvate dehydrogenase kinase (EC 2.7.11.2)|

* PDK1
* PDK2
* PDK3
* PDK4

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)|

* AMP-activated protein kinase α
* PRKAA1
* PRKAA2
* β
* PRKAB1
* PRKAB2
* γ
* PRKAG1
* PRKAG2
* PRKAG3

3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)|

* BCKDK
* BCKDHA
* BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)|

* IDH2
* IDH3A
* IDH3B
* IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)|

* STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)|

* Aurora kinase
* Aurora A kinase
* Aurora B kinase
* Aurora C kinase

Fas-activated serine/threonine kinase (EC 2.7.11.8)|

* FASTK
* STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)|

* -

IκB kinase (EC 2.7.11.10)|

* CHUK
* IKK2
* TBK1
* IKBKE
* IKBKG
* IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)|

* Protein kinase A
* PRKACG
* PRKACB
* PRKACA
* PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)|

* Protein kinase G
* PRKG1

Protein kinase C (EC 2.7.11.13)|

* Protein kinase C
* Protein kinase Cζ
* PKC alpha
* PRKCB1
* PRKCD
* PRKCE
* PRKCH
* PRKCG
* PRKCI
* PRKCQ
* Protein kinase N1
* PKN2
* PKN3

Rhodopsin kinase (EC 2.7.11.14)|

* Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)|

* Beta adrenergic receptor kinase
* Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)|

* GRK4
* GRK5
* GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)|

* BRSK2
* CAMK1
* CAMK1A
* CAMK1B
* CAMK1D
* CAMK1G
* CAMK2
* CAMK2A
* CAMK2B
* CAMK2D
* CAMK2G
* CAMK4
* MLCK
* CASK
* CHEK1
* CHEK2
* DAPK1
* DAPK2
* DAPK3
* STK11
* MAPKAPK2
* MAPKAPK3
* MAPKAPK5
* MARK1
* MARK2
* MARK3
* MARK4
* MELK
* MKNK1
* MKNK2
* NUAK1
* NUAK2
* OBSCN
* PASK
* PHKG1
* PHKG2
* PIM1
* PIM2
* PKD1
* PRKD2
* PRKD3
* PSKH1
* SNF1LK2
* KIAA0999
* STK40
* SNF1LK
* SNRK
* SPEG
* TSSK2
* Kalirin
* TRIB1
* TRIB2
* TRIB3
* TRIO
* Titin
* DCLK1

Myosin light-chain kinase (EC 2.7.11.18)|

* MYLK
* MYLK2
* MYLK3
* MYLK4

Phosphorylase kinase (EC 2.7.11.19)|

* PHKA1
* PHKA2
* PHKB
* PHKG1
* PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)|

* EEF2K
* STK19

Polo kinase (EC 2.7.11.21)|

* PLK1
* PLK2
* PLK3
* PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

| Polo kinase (EC 2.7.11.21)|

* PLK1
* PLK2
* PLK3
* PLK4

|

Cyclin-dependent kinase (EC 2.7.11.22)|

* CDK1
* CDK2
* CDKL2
* CDK3
* CDK4
* CDK5
* CDKL5
* CDK6
* CDK7
* CDK8
* CDK9
* CDK10
* CDK12
* CDC2L5
* PCTK1
* PCTK2
* PCTK3
* PFTK1
* CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)|

* RPS6KA5
* RPS6KA4
* P70S6 kinase
* P70-S6 Kinase 1
* RPS6KB2
* RPS6KA2
* RPS6KA3
* RPS6KA1
* RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)|

* Extracellular signal-regulated
* MAPK1
* MAPK3
* MAPK4
* MAPK6
* MAPK7
* MAPK12
* MAPK15
* C-Jun N-terminal
* MAPK8
* MAPK9
* MAPK10
* P38 mitogen-activated protein
* MAPK11
* MAPK13
* MAPK14

MAP3K (EC 2.7.11.25)|

* MAP kinase kinase kinases
* MAP3K1
* MAP3K2
* MAP3K3
* MAP3K4
* MAP3K5
* MAP3K6
* MAP3K7
* MAP3K8
* RAFs
* ARAF
* BRAF
* KSR1
* KSR2
* MLKs
* MAP3K12
* MAP3K13
* MAP3K9
* MAP3K10
* MAP3K11
* MAP3K7
* ZAK
* CDC7
* MAP3K14

Tau-protein kinase (EC 2.7.11.26)|

* TPK1
* TTK
* GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)|

* -

Tropomyosin kinase (EC 2.7.11.28)|

* -

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)|

* -

Receptor protein serine/threonine kinase (EC 2.7.11.30)|

* Bone morphogenetic protein receptors
* BMPR1
* BMPR1A
* BMPR1B
* BMPR2
* ACVR1
* ACVR1B
* ACVR1C
* ACVR2A
* ACVR2B
* ACVRL1
* Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

| MAP2K|

* MAP2K1
* MAP2K2
* MAP2K3
* MAP2K4
* MAP2K5
* MAP2K6
* MAP2K7

|

* v
* t
* e

TGFβ receptor superfamily modulators

Type I|

| ALK1 (ACVRL1)|

* Agonists: Activin (A, B, AB)
* Avotermin
* BMP (10)
* Cetermin
* GDF (2 (BMP9))
* TGFβ (1, 2, 3)

* Antibodies: Ascrinvacumab

* Kinase inhibitors: K-02288
* ML-347 (LDN-193719, VU0469381)

* Decoy receptors: Dalantercept

* Other inhibitors: Disitertide

|

ALK2 (ACVR1A)|

* Agonists: Activin (A, B, AB)
* AMH (MIS)
* Avotermin
* BMP (5, 6, 7, 8A, 8B)
* Eptotermin alfa
* TGFβ (1, 2, 3)

* Kinase inhibitors: DMH-1
* DMH-2
* Dorsomorphin (BML-275)
* K-02288
* ML-347 (LDN-193719, VU0469381)

ALK3 (BMPR1A)|

* Agonists: AMH (MIS)
* BMP (2, 4, 5, 6, 7, 8A, 8B)
* Dibotermin alfa
* Eptotermin alfa

* Kinase inhibitors: DMH-2
* Dorsomorphin (BML-275)
* K-02288

ALK4 (ACVR1B)|

* Agonists: Activin (A, B, AB)
* GDF (1, 3, 11 (BMP11))
* Myostatin (GDF8)
* Nodal

* Antagonists: Inhibin (A, B)
* Lefty (1, 2)

* Kinase inhibitors: A 83-01
* SB-431542
* SB-505124

ALK5 (TGFβR1)|

* Agonists: Avotermin
* GDF (10 (BMP3B), 11 (BMP11))
* TGFβ (1, 2, 3)

* Antibodies: Fresolimumab
* Lerdelimumab
* Metelimumab

* Kinase inhibitors: A 83-01
* D-4476
* GW-788388
* LY-364947
* LY-2109761
* Galunisertib (LY-2157299)
* R-268712
* RepSox (E-616452, SJN-2511)
* SB-431542
* SB-505124
* SB-525334
* SD-208

ALK6 (BMPR1B)|

* Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
* Dibotermin alfa
* Eptotermin alfa
* GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15)
* Radotermin

* Kinase inhibitors: DMH-2
* Dorsomorphin (BML-275)
* K-02288

ALK7 (ACVR1C)|

* Agonists: GDF (1, 3, 11 (BMP11))
* Nodal

* Antagonists: Lefty (1, 2)

* Kinase inhibitors: A 83-01
* SB-431542
* SB-505124

Type II|

| TGFβR2|

* Agonists: Avotermin
* GDF (10 (BMP3B))
* TGFβ (1, 2, 3)

* Antibodies: Fresolimumab
* Lerdelimumab
* Metelimumab

* Kinase inhibitors: DMH-2
* LY-364947

|

BMPR2|

* Agonists: BMP (2, 4, 6, 7, 10)
* Dibotermin alfa
* Eptotermin alfa
* GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12))
* Radotermin

* Antagonists: Inhibin (A, B)

ACVR2A (ACVR2)|

* Agonists: Activin (A, B, AB)
* BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
* Dibotermin alfa
* Eptotermin alfa
* GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15)
* Myostatin (GDF8)
* Nodal
* Radotermin

* Antagonists: Inhibin (A, B)
* Lefty (1, 2)

* Decoy receptors: Sotatercept

ACVR2B|

* Agonists: Activin (A, B, AB)
* BMP (2, 4, 6, 7)
* Dibotermin alfa
* Eptotermin alfa
* GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12))
* Myostatin (GDF8)
* Nodal
* Osteogenin (BMP3, BMP3A)
* Radotermin

* Antagonists: Inhibin (A, B)
* Lefty (1, 2)

* Decoy receptors: Ramatercept

AMHR2 (AMHR)|

* Agonists: AMH (MIS)

Type III|

| TGFβR3 (β-glycan)|

* Ligands: Avotermin
* Inhibin (A, B)
* TGFβ (1, 2, 3)

|

Unsorted|

* Endogenous antagonists/inhibitors: BAMBI
* Cerberus (CER1)
* Chordin
* DAN (PARN)
* Decorin
* Follistatin
* Gremlin (Drm)
* LTBP1
* Noggin
* TGIF
* Thrombospondin 1 (THBS1)
* Tomoregulin 1

* Antibodies: Stamulumab (against myostatin)
* TRC105 (against endoglin)

* Others: Endoglin

See also
Receptor/signaling modulators
Signaling peptide/protein receptor modulators
Growth factor receptor modulators
Cytokine receptor modulators

Stub icon| This article about a biochemical receptor is a stub. You can help Wikipedia by expanding it.

* v
* t
* e

|

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[TGFβ]: Transforming growth factor beta
*[ALK1]: Activin receptor-like kinase 1
*[ACVRL1]: Activin A receptor-like type 1
*[ALK2]: Activin receptor-like kinase 2
*[ACVR1A]: Activin A receptor type 1A
*[ALK3]: Activin receptor-like kinase 3
*[BMPR1A]: Bone morphogenetic protein receptor type 1A
*[ALK4]: Activin receptor-like kinase 4
*[ACVR1B]: Activin A receptor type 1B
*[ALK5]: Activin receptor-like kinase 5
*[TGFβR1]: Transforming growth factor beta receptor 1
*[ALK6]: Activin receptor-like kinase 6
*[BMPR1B]: Bone morphogenetic protein receptor type 1B
*[ALK7]: Activin receptor-like kinase 7
*[ACVR1C]: Activin A receptor type 1C
*[TGFβR2]: Transforming growth factor beta receptor 2
*[BMPR2]: Bone morphogenetic protein receptor type 2
*[ACVR2A]: Activin receptor type 2A
*[ACVR2]: Activin receptor type 2
*[ACVR2B]: Activin receptor type 2B
*[AMHR2]: Anti-Müllerian hormone receptor type 2
*[AMHR]: Anti-Müllerian hormone receptor
*[TGFβR3]: Transforming growth factor beta receptor 3