TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

Identifiers
Symbol| TIRAP
Entrez| 114609
HUGO| 17192
OMIM| 606252
RefSeq| NM_148910
UniProt| P58753
Other data
Locus| Chr. 11 q24.2

TIRAP is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

## See also

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* Myd88

## External links

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* TIRAP+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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Signaling pathway: TLR signaling pathway

Receptor|

* TLR 4

* TLR 1
* TLR 2
* TLR 6

* TLR 5
* TLR 10

Other external|

* CD14
* MD2
* LBP

Internal|

* adaptor: MYD88
* TRIF
* TIRAP
* TRAF6
* TOLLIP

* IRAK1
* IRAK4

* IRF3

* TLR 3
* TLR 7
* TLR 8
* TLR 9

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