The WikiDoc Living Textbook of Hematology

##  Click Here For A Complete Listing Of All Chapters In The Living Textbook Of Hematology In Alphabetical Order

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##  Click Here For Status Update Of Hematology

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## Anatomy and Physiology

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Template:Blood

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HLA-A serotypes

Template:Nowrap begin HLA-ATemplate:·w A1Template:·w A2Template:·w A3Template:·w A9 (A23Template:·w A24)Template:·w A10 (A25Template:·w A26Template:·w A34Template:·w A43Template:·w A66)Template:·w A11Template:·w A19 (A29Template:·w A30Template:·w A31Template:·w A32Template:·w A33Template:·w A74)Template:·w A28 (A68Template:·w A69)Template:·w A36Template:·w A80 Template:Nowrap end

Template:HLAB Template:HLACW

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Proteins involved in coagulation

Coagulation factors|

| Primary hemostasis|

* vWF
* platelet membrane glycoproteins: Ib (A
* B
* IX)
* IIb/IIIa (IIb
* IIIa)
* VI

|

Intrinsic pathway|

* HMWK/Bradykinin
* Prekallikrein/Kallikrein
* XII "Hageman"
* XI
* IX
* VIII

Extrinsic pathway|

* III "Tissue factor"
* VII

Common pathway|

* X
* V
* II "(Pro)thrombin"
* I "Fibrin"
* Fibrinogen (FGA, FGG)
* XIII

Coagulation inhibitors|

* Antithrombin (inhibits II, IX, X, XI, XII)
* Protein C (inhibits V, VIII)/Protein S (cofactor for protein C)
* Protein Z (inhibits X)
* ZPI (inhibits X, XI)
* TFPI (inhibits III)

Thrombolysis/fibrinolysis|

* Plasmin
* tPA/urokinase
* PAI-1/2
* α2-AP
* α2-macroglobulin
* TAFI

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Serpins

inhibitory|

* Alpha 1-antichymotrypsin
* Alpha 1-antitrypsin
* Alpha 2-antiplasmin
* Antithrombin
* C1-inhibitor
* Heparin cofactor II
* Protein C inhibitor
* Plasminogen activator inhibitor-1
* Plasminogen activator inhibitor-2
* Protein Z-related protease inhibitor

* SERPINA1
* SERPINA2
* SERPINA3
* SERPINA4
* SERPINA5
* SERPINA9
* SERPINA14

* SERPINB1
* SERPINB2
* SERPINB3
* SERPINB4
* SERPINB5
* SERPINB6
* SERPINB7
* SERPINB8
* SERPINB9
* SERPINB13

* SERPINC1
* SERPIND1
* SERPINE1
* SERPINE2
* SERPINE2
* SERPINF1
* SERPING1
* SERPINH1
* SERPINI1
* SERPINI2

Cross class inhibitory|

* MENT
* SCCA-1
* CrmA

noninhibitory|

* Heat shock protein 47
* Maspin
* Ovalbumin
* SERPINF1
* Transcortin
* Thyroxine-binding globulin
* Angiotensinogen
* SERPINF1

see also disorders of globin and globulin proteins

## Disease States

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Template:Hematology

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Proteins involved in coagulation

Coagulation factors|

| Primary hemostasis|

* vWF
* platelet membrane glycoproteins: Ib (A
* B
* IX)
* IIb/IIIa (IIb
* IIIa)
* VI

|

Intrinsic pathway|

* HMWK/Bradykinin
* Prekallikrein/Kallikrein
* XII "Hageman"
* XI
* IX
* VIII

Extrinsic pathway|

* III "Tissue factor"
* VII

Common pathway|

* X
* V
* II "(Pro)thrombin"
* I "Fibrin"
* Fibrinogen (FGA, FGG)
* XIII

Coagulation inhibitors|

* Antithrombin (inhibits II, IX, X, XI, XII)
* Protein C (inhibits V, VIII)/Protein S (cofactor for protein C)
* Protein Z (inhibits X)
* ZPI (inhibits X, XI)
* TFPI (inhibits III)

Thrombolysis/fibrinolysis|

* Plasmin
* tPA/urokinase
* PAI-1/2
* α2-AP
* α2-macroglobulin
* TAFI

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Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)

CFU-GM/
and other granulocytes|

Template:Navbox subgroup

MEP|

Template:Navbox subgroup

CFU-Mast|

Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)

Multiple/unknown|

AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) * MP (Myelofibrosis) * Acute biphenotypic leukaemia

See also hematology, lymphoid malignancy

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Transfusion medicine

General concepts|

* Apheresis (plasmapheresis, plateletpheresis, leukapheresis)
* Blood transfusion
* Coombs test (direct and indirect)
* Cross-matching
* Exchange transfusion
* International Society of Blood Transfusion
* Intraoperative blood salvage
* ISBT 128
* Transfusion reactions

Blood group systems /
blood types|

* ABO
* Chido-Rodgers
* Colton
* Cromer
* Diego
* Dombrock
* Duffy
* Er
* FORS
* Gerbich
* GIL
* GLOB
* Hh
* Ii
* Indian
* JR
* JMH
* Kell (Xk)
* Kidd
* Knops
* Lan
* Lewis
* Lutheran
* LW
* MNS
* OK
* P
* Raph
* Rh and RHAG
* Scianna
* T-Tn
* Vel
* Xg
* Yt
* Other

Blood products /
blood donation|

* Whole blood
* Platelets
* Red blood cells
* Plasma / Fresh frozen plasma / PF24 (Cryoprecipitate \+ Cryosupernatant)
* Blood substitutes

Template:HDN

## Pharmacotherapy

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Antihemorrhagics (B02)

Antihemorrhagics
(coagulation)|

| Systemic|

| Vitamin K|

* Phytomenadione (K1)
* Menadione (K3)

|

Coagulation
factors|

* intrinsic: IX/Nonacog alfa
* VIII/Moroctocog alfa/Turoctocog alfa

* extrinsic: VII/Eptacog alfa

* common: X
* II/Thrombin
* I/Fibrinogen
* XIII/Catridecacog

* combinations: Prothrombin complex concentrate (II, VII, IX, X, protein C and S)

Other
systemic|

* Etamsylate
* Carbazochrome
* Batroxobin
* thrombopoietin receptor agonist (Romiplostim
* Avatrombopag
* Eltrombopag
* Lusutrombopag)

Local|

* Absorbable gelatin sponge
* Oxidized cellulose
* Tetragalacturonic acid hydroxymethylester
* Thrombin
* Collagen
* Calcium alginate
* Epinephrine/Adrenalone

Antifibrinolytics|

* amino acids (Aminocaproic acid
* Tranexamic acid
* Aminomethylbenzoic acid)
serpins (Aprotinin
* Alfa1 antitrypsin
* C1-inhibitor
* Camostat)

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