Transient hypogammaglobulinemia of infancy

ICD-10 | D80.7
ICD-9 | 279.09
eMedicine | ped/2280

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth, leading to a reduction in the level of IgG, and also sometimes IgA[1] and IgM.[2] (The ratios of immunoglobulins vary rapidly in all infants, and the term dysgammaglobulinemia, although theoretically applicable, isn't usually used in this context.)

It can result in increased infections, but it can also present without symptoms.[3]

## Historical Perspective

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## Classification

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## Pathophysiology

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## Causes

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## Differentiating Transient hypogammaglobulinemia of infancy from Other Diseases

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## Epidemiology and Demographics

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## Risk Factors

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## Screening

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## Natural History, Complications, and Prognosis

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### Natural History

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### Complications

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### Prognosis

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## Diagnosis

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### Diagnostic Criteria

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### History and Symptoms

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### Physical Examination

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### Laboratory Findings

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### Imaging Findings

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### Other Diagnostic Studies

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## Treatment

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### Medical Therapy

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### Surgery

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### Prevention

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## References

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1. ↑ "Transient Hypogammaglobulinemia of Infancy: Immunodeficiency Disorders: Merck Manual Professional". Retrieved 2008-03-01.
2. ↑ Kiliç SS, Tezcan I, Sanal O, Metin A, Ersoy F (2000). "Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases". Pediatr Int. 42 (6): 647–50. PMID 11192522.CS1 maint: Multiple names: authors list (link)
3. ↑ Hsueh KC, Chiu HH, Lin HC, Hsu CH, Tsai FJ (2005). "Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection". J Microbiol Immunol Infect. 38 (2): 141–4. PMID 15843860.CS1 maint: Multiple names: authors list (link)

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