Transmembrane Protein 175

Identifiers
Symbol| TMEM175
Pfam| PF06736
InterPro| IPR010617
TCDB| 1.A.78
OPM superfamily| 467
OPM protein| 5vre
| Available protein structures:

Pfam| structures
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary
Transmembrane Protein 175

Identifiers
Symbol| TMEM175
Alt. symbols| MGC4618
Entrez| 84286
HUGO| 28709
RefSeq| NM_032326
UniProt| Q9BSA9
Other data
Locus| Chr. 4 p16.3

Transmembrane Protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

## Contents

* 1 Expression
* 2 Homology
* 3 Predicted Post-Translational Modification
* 4 References

## Expression

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Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level(75-98%) in normal tissues.[1][2] TMEM175 appears to be down regulated in stage three ovarian cancer[3]

## Homology

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Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLAST[4]and BLAT. [5] This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.

Scientific name | Common Name | Accession Number | Sequence Length | Percent Identity | Percent Similarity

|
|
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|
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Homo Sapiens | Human | NP_115702.1 | 504 | - | \-
Pan troglodytes | Chimp | XP_001141076 | 504 | 92 | 93
Pongo abelii | Orangutan | XP_002814537 | 231 | 99 | 99
Macaca mulatta | Rhesus | XP_001085173.1 | 403 | 96 | 98
Callithrix jacchus | Marmoset | XP_002746113.1 | 472 | 83 | 87
Bos taurus | Cow | NP_001069081.1 | 479 | 77 | 82
Ailuropoda melanoleuca | Panda | XP_002924455.1 | 498 | 81 | 87
Equus caballus | Horse | XP_001488271.1 | 499 | 81 | 86
Rattus norvegicus | Rat | NP_001014013.1 | 499 | 82 | 88
Mus musculus | Mouse | NP_082499.3 | 499 | 81 | 88
Monodelphis domestica | Opossum | XP_001377424.1 | 502 | 67 | 80
Ornithorhynchus anatinus | Platypus | XP_001514176 | 499 | 68 | 82
Gallus gallus | Chicken | NP_001006582.1 | 501 | 64 | 78
Sceloporus occidentalis | Lizard | - | 417 | 56 | 66
Taeniopygia guttata | Zebra Finch | XP_002187908.1 | 496 | 66 | 79
Danio rerio | Zebra Fish | NP_001093545.1 | 520 | 62 | 76
Branchiostoma floridae | Lancelet | XP_002596272 | 409 | 31 | 50
Ciona intestinalis | Sea Squirt | XP_002122718 | 494 | 27 | 50
Nematostella vectensis | Starlet Sea Anemone | XP_001630719 | 489 | 28 | 49

## Predicted Post-Translational Modification

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Using various tools at ExPASy[6] the following are possible post-translational modifications for TMEM175.

* 5 possible CK2 phosphorylation sites
* 2 possible PKC phosphorylation sites
* N-myristoylation sites around transmembrane regions

The N-myristoylation sites are conserved in vertebrates.

## References

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1. ↑ EST Profile Viewer- Human
2. ↑ EST Profile Viewer- Mouse
3. ↑ [Partheen K, Levan K, Osterberg L, Horvath G (November 2006). "Expression analysis of stage III serous ovarian adenocarcinoma distinguishes a sub-group of survivors". European Journal of Cancer. 42 (16): 2846–54. doi:10.1016/j.ejca.2006.06.026. PMID 16996261.
4. ↑ NCBI BLAST: Basic Local Alignment Search Tool
5. ↑ BLAT Search Genome[permanent dead link]
6. ↑ ExPASy Proteomics Server