Tumor-associated calcium signal transducer 1

Identifiers
Symbols|  TACSTD1 ; CD326; CO17-1A; EGP; EGP40; Ep-CAM; GA733-2; KSA; M4S1; MIC18; MK-1; TROP1; hEGP-2
External IDs|  Template:OMIM5 Template:MGI HomoloGene: 1764
| Gene ontology

Cellular component | Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TACSTD1 201839 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

Tumor-associated calcium signal transducer 1, also known as TACSTD1, is a human gene.[1] TACSTD1 has also been designated as CD326 (cluster of differentiation 326).

This 9-exon gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas.[1]

## References[edit | edit source]

1. ↑ 1.0 1.1 "Entrez Gene: TACSTD1 tumor-associated calcium signal transducer 1".

## Further reading[edit | edit source]

* Bergsagel PL, Victor-Kobrin C, Timblin CR; et al. (1992). "A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells". J. Immunol. 148 (2): 590–6. PMID 1729376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Simon B, Podolsky DK, Moldenhauer G; et al. (1990). "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2755–9. PMID 2108441.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Szala S, Froehlich M, Scollon M; et al. (1990). "Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3542–6. PMID 2333300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Strnad J, Hamilton AE, Beavers LS; et al. (1989). "Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA". Cancer Res. 49 (2): 314–7. PMID 2463074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Perez MS, Walker LE (1989). "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker". J. Immunol. 142 (10): 3662–7. PMID 2469722.
* Linnenbach AJ, Wojcierowski J, Wu SA; et al. (1989). "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 27–31. PMID 2911574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Spurr NK, Durbin H, Sheer D; et al. (1986). "Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI". Int. J. Cancer. 38 (5): 631–6. PMID 3770992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Björk P, Jönsson U, Svedberg H; et al. (1993). "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody". J. Biol. Chem. 268 (32): 24232–41. PMID 7693697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Linnenbach AJ, Seng BA, Wu S; et al. (1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol. Cell. Biol. 13 (3): 1507–15. PMID 8382772.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Zhong XY, Kaul S, Eichler A, Bastert G (2000). "Evaluating GA733-2 mRNA as a marker for the detection of micrometastatic breast cancer in peripheral blood and bone marrow". Arch. Gynecol. Obstet. 263 (1–2): 2–6. PMID 10728619.CS1 maint: Multiple names: authors list (link)
* Tomita Y, Arakawa F, Yamamoto T; et al. (2000). "Molecular identification of a human carcinoma-associated glycoprotein antigen recognized by mouse monoclonal antibody FU-MK-1". Jpn. J. Cancer Res. 91 (2): 231–8. PMID 10761711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Trebak M, Begg GE, Chong JM; et al. (2001). "Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion". J. Biol. Chem. 276 (3): 2299–309. doi:10.1074/jbc.M004770200. PMID 11058587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Chong JM, Speicher DW (2001). "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)". J. Biol. Chem. 276 (8): 5804–13. doi:10.1074/jbc.M008839200. PMID 11080501.
* Calabrese G, Crescenzi C, Morizio E; et al. (2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet. Cell Genet. 92 (1–2): 164–5. PMID 11306819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Meyaard L, van der Vuurst de Vries AR, de Ruiter T; et al. (2001). "The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR)". J. Exp. Med. 194 (1): 107–12. PMID 11435477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lammers R, Giesert C, Grünebach F; et al. (2002). "Monoclonal antibody 9C4 recognizes epithelial cellular adhesion molecule, a cell surface antigen expressed in early steps of erythropoiesis". Exp. Hematol. 30 (6): 537–45. PMID 12063020.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Spizzo G, Gastl G, Wolf D; et al. (2003). "Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival". Br. J. Cancer. 88 (4): 574–8. doi:10.1038/sj.bjc.6600741. PMID 12592372.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Nasr AF, Nutini M, Palombo B; et al. (2003). "Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene". Oncogene. 22 (11): 1668–77. doi:10.1038/sj.onc.1206248. PMID 12642870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Gires O, Eskofier S, Lang S; et al. (2003). "Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter". Anticancer Res. 23 (4): 3255–61. PMID 12926061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

## External links[edit | edit source]

* TACSTD1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50|

* CD1
* a-c
* 1A
* 1D
* 1E
* CD2
* CD3
* γ
* δ
* ε
* CD4
* CD5
* CD6
* CD7
* CD8
* a
* CD9
* CD10
* CD11
* a
* b
* c
* d
* CD13
* CD14
* CD15
* CD16
* A
* B
* CD18
* CD19
* CD20
* CD21
* CD22
* CD23
* CD24
* CD25
* CD26
* CD27
* CD28
* CD29
* CD30
* CD31
* CD32
* A
* B
* CD33
* CD34
* CD35
* CD36
* CD37
* CD38
* CD39
* CD40
* CD41
* CD42
* a
* b
* c
* d
* CD43
* CD44
* CD45
* CD46
* CD47
* CD48
* CD49
* a
* b
* c
* d
* e
* f
* CD50

51-100|

* CD51
* CD52
* CD53
* CD54
* CD55
* CD56
* CD57
* CD58
* CD59
* CD61
* CD62
* E
* L
* P
* CD63
* CD64
* A
* B
* C
* CD66
* a
* b
* c
* d
* e
* f
* CD68
* CD69
* CD70
* CD71
* CD72
* CD73
* CD74
* CD78
* CD79
* a
* b
* CD80
* CD81
* CD82
* CD83
* CD84
* CD85
* a
* d
* e
* h
* j
* k
* CD86
* CD87
* CD88
* CD89
* CD90
* CD91 \- CD92
* CD93
* CD94
* CD95
* CD96
* CD97
* CD98
* CD99
* CD100

101-150|

* CD101
* CD102
* CD103
* CD104
* CD105
* CD106
* CD107
* a
* b
* CD108
* CD109
* CD110
* CD111
* CD112
* CD113
* CD114
* CD115
* CD116
* CD117
* CD118
* CD119
* CD120
* a
* b
* CD121
* a
* b
* CD122
* CD123
* CD124
* CD125
* CD126
* CD127
* CD129
* CD130
* CD131
* CD132
* CD133
* CD134
* CD135
* CD136
* CD137
* CD138
* CD140b
* CD141
* CD142
* CD143
* CD144
* CD146
* CD147
* CD148
* CD150

151-200|

* CD151
* CD152
* CD153
* CD154
* CD155
* CD156
* a
* b
* c
* CD157
* CD158 (a
* d
* e
* i
* k)
* CD159
* a
* c
* CD160
* CD161
* CD162
* CD163
* CD164
* CD166
* CD167
* a
* b
* CD168
* CD169
* CD170
* CD171
* CD172
* a
* b
* g
* CD174
* CD177
* CD178
* CD179
* a
* b
* CD180
* CD181
* CD182
* CD183
* CD184
* CD185
* CD186
* CD191
* CD192
* CD193
* CD194
* CD195
* CD196
* CD197
* CDw198
* CDw199
* CD200

201-250|

* CD201
* CD202b
* CD204
* CD205
* CD206
* CD207
* CD208
* CD209
* CDw210
* a
* b
* CD212
* CD213a
* 1
* 2
* CD217
* CD218 (a
* b)
* CD220
* CD221
* CD222
* CD223
* CD224
* CD225
* CD226
* CD227
* CD228
* CD229
* CD230
* CD233
* CD234
* CD235
* a
* b
* CD236
* CD238
* CD239
* CD240CE
* CD240D
* CD241
* CD243
* CD244
* CD246
* CD247 \- CD248
* CD249

251-300|

* CD252
* CD253
* CD254
* CD256
* CD257
* CD258
* CD261
* CD262
* CD263
* CD264
* CD265
* CD266
* CD267
* CD268
* CD269
* CD271
* CD272
* CD273
* CD274
* CD275
* CD276
* CD278
* CD279
* CD280
* CD281
* CD282
* CD283
* CD284
* CD286
* CD288
* CD289
* CD290
* CD292
* CDw293
* CD294
* CD295
* CD297
* CD298
* CD299

301-350|

* CD300A
* CD301
* CD302
* CD303
* CD304
* CD305
* CD306
* CD307
* CD309
* CD312
* CD314
* CD315
* CD316
* CD317
* CD318
* CD320
* CD321
* CD322
* CD324
* CD325
* CD326
* CD328
* CD329
* CD331
* CD332
* CD333
* CD334
* CD335
* CD336
* CD337
* CD338
* CD339
* CD340
* CD344
* CD349
* CD350

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