Tumor necrosis factor receptor

## Contents

* 1 Overview
* 2 Members
* 3 References
* 4 External links

## Overview

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A tumor necrosis factor receptor (TNFR) is, as its name would indicate, a receptor which binds tumor necrosis factors (TNF).

Because "TNF" is often used to describe TNF alpha, "TNFR" is often used to describe the receptors that bind to TNF alpha - namely, CD120. However, there several other members of this family that bind to the other TNFs.[1][2]

## Members

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Family members include:[1]

* type 1
* CD120 \- TNFRSF1A
* TNFRSF1B
* type 3
* Lymphotoxin beta receptor \- LTBR
* type 4
* CD134 \- TNFRSF4
* type 5
* CD40 \- CD40
* type 6
* FAS \- FAS
* TNFRSF6B
* type 7
* CD27 \- CD27
* type 8
* CD30 \- TNFRSF8
* type 9
* CD137 \- TNFRSF9
* type 10
* TNFRSF10A \- TNFRSF10A
* TNFRSF10B \- TNFRSF10B
* TNFRSF10C
* TNFRSF10D
* type 11
* RANK \- TNFRSF11A
* Osteoprotegerin \- TNFRSF11B
* type 12
* TNFRSF12A
* type 13
* TNFRSF13B
* TNFRSF13C
* type 14
* TNFRSF14
* type 16
* Nerve growth factor receptor \- NGFR
* type 17
* TNFRSF17
* type 18
* TNFRSF18
* type 19
* TNFRSF19
* RETL
* type 21
* TNFRSF21
* type 25
* TNFRSF25

## References

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1. ↑ 1.0 1.1 Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.CS1 maint: Multiple names: authors list (link)
2. ↑ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMID 15819693.

## External links

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* Tumor+Necrosis+Factor+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Transmembrane receptors: immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor|

| Epsilon (ε)|

* FcεRI
* (FcεRII is C-type lectin)

|

Gamma (γ)|

* FcγRI
* FcγRII
* FcγRIII
* Neonatal

Alpha (α)/mu (μ)|

* FcαRI
* Fcα/μR

Secretory|

* Polymeric immunoglobulin receptor

Antigen receptor|

| B cells|

| Antigen receptor|

* BCR

|

Co-receptor|

| stimulate:|

* CD21/CD19/CD81

|

inhibit:|

* CD22

Accessory molecules|

* Ig-α/Ig-β (CD79)

T cells|

| Ligands|

* MHC
* MHC class I
* MHC class II

|

Antigen receptor|

* TCR: TRA@
* TRB@
* TRD@
* TRG@

Co-receptors|

* CD8 (with two glycoprotein chains CD8α and CD8β)
* CD4

Accessory molecules|

* CD3
* CD3γ
* CD3δ
* CD3ε
* ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor|

* see cytokine receptors

Killer-cell IG-like receptors|

* KIR2DL1
* KIR2DL2
* KIR2DL3
* KIR2DL4
* KIR2DL5A
* KIR2DL5B
* KIR2DS1
* KIR2DS2
* KIR2DS3
* KIR2DS4
* KIR2DS5
* KIR3DL1
* KIR3DL2
* KIR3DL3
* KIR3DS1

Leukocyte IG-like receptors|

* LILRA1
* LILRA2
* LILRA3
* LILRA4
* LILRA5
* LILRA6
* LILRB1
* LILRB2
* LILRB3
* LILRB4
* LILRB5
* LILRA6
* LILRA5

* v
* t
* e

Cytokine receptors

Chemokine receptor
(GPCRs)|

| CC|

* CCR1 / CCRL1
* CCR2
* CCRL2
* CCR3
* CCR4
* CCR5
* CCR6
* CCR7
* CCR8
* CCR9
* CCR10

|

CXC|

* IL-8
* CXCR1
* CXCR2
* CXCR3
* CXCR4
* CXCR5
* CXCR6
* CXCR7

Other|

* CX3C
* CX3CR1
* XC
* XCR1
* CCBP2
* CMKLR1

TNF receptor|

| 1-10|

* TNFR1 (TNFRSF1A)
* TNFR2 (TNFRSF1B)
* LTBR (TNFRSF3)
* CD134 (TNFRSF4)
* CD40 (TNFRSF5)
* Fas receptor (TNFRSF6)
* DcR3 (TNFRSF6B)
* CD27 (TNFRSF7)
* CD30 (TNFRSF8)
* CD137 (TNFRSF9)

|

11-20|

* DR4 (TNFRSF10A)
* DR5 (TNFRSF10B)
* DcR1 (TNFRSF10C)
* DcR2 (TNFRSF10D)
* RANK (TNFRSF11A)
* Osteoprotegerin (TNFRSF11B)
* TweakR (TNFRSF12A)
* TACI (TNFRSF13B)
* BAFFR (TNFRSF13C)
* HVEM (TNFRSF14)
* NGFR (TNFRSF16)
* BCMA (TNFRSF17)
* GITR (TNFRSF18)
* TAJ/TROY (TNFRSF19)

21-27|

* DR6 (TNFRSF21)
* DR3 (TNFRSF25)
* EDA2R (TNFRSF27)

JAK-STAT|

| Type I|

| γ-chain|

* Interleukin receptors
* IL2R / IL2RA/IL2RB / IL15R
* IL4R / IL13R / IL13RA1 / IL13RA2
* IL7R / IL7RA
* IL9R
* IL21R

|

β-chain|

* Interleukin receptors
* IL3R / IL3RA
* IL5R / IL5RA
* GM-CSF

gp130|

* Interleukin receptors
* IL6RA
* 11/IL11RA
* 27/IL27RA
* OSMR
* LIFR
* CNTFR

IL12RB1|

* Interleukin receptors
* IL12R/IL12RB1/IL12RB2
* IL23R23

Other|

* other CSF receptors
* EPO
* G-CSF
* Thrombopoietin

* hormone receptor: GH
* prolactin

Type II|

* Interleukin receptors
* IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
* IL20R / IL20RA / IL20RB
* IL28R
* Interferon receptors
* -α/β / IFNAR1/IFNAR2
* -γ/IFNGR1 / IFNGR2

Ig superfamily|

* CSF1
* KIT
* IL1
* IL1R1
* IL1R2
* IL18R / IL18R1

IL 17 family|

* IL17
* IL17RA
* IL17RB
* IL17RC
* IL17RD
* IL17RE

S/T|

* TGF-beta
* TGFBR1
* TGFBR2

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