Upper motor neuron

Template:Infobox Anatomy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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Upper motor neurons are any neurons that originate in motor region of the cerebral cortex and/or the brain stem and carry motor information down to the final common pathway, that is, any motor neurons that are not directly responsible for stimulating the target muscle. The main effector neurons for voluntary movement lie within layer V of the primary motor cortex and are called Betz cells. The cell bodies of these neurons are some of the largest in the brain, approaching nearly 100μm in diameter.

These neurons connect the brain to the appropriate level in the spinal cord, from which point nerve signals continue to the muscles by means of the lower motor neurons. The neurotransmitter glutamate transmits the nerve impulses from upper to lower motor neurons where it is detected by glutamatergic receptors.

## Pathways

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Upper motor neurons travel in several pathways through the CNS:

Tract | Pathway | Function

|
|

corticospinal tract | from the motor cortex to lower motor neurons in the ventral horn of the spinal cord | The major function of this pathway is fine voluntary motor control of the limbs. The pathway also controls voluntary body posture adjustments.
corticobulbar tract | from the motor cortex to several nuclei in the pons and medulla | Involved in involuntary maintenance of body posture.
tectospinal tract/colliculospinal tract | from the superior colliculus to lower motor neurons | Involved in involuntary adjustment of head position in response to visual information.
rubrospinal tract | from red nucleus to lower motor neurons | Involved in involuntary adjustment of arm position in response to balance information.
vestibulospinal tract | from vestibular nuclei, which processes stimuli from semicircular canals | It is responsible for adjusting posture to maintain balance.
reticulospinal tract | from reticular formation | Regulates various involuntary motor activities and assists in balance.

## Lesions

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Upper motor neurone lesions are indicated by spasticity, exaggerated reflexes, loss of voluntary motor control and the Babinski sign.

* v
* t
* e

Nervous tissue

CNS|

| Tissue Types|

* Grey matter
* White matter
* Projection fibers
* Association fiber
* Commissural fiber
* Lemniscus
* Nerve tract
* Decussation
* Commissure
* Neuropil
* Meninges

|

Cell Types|

| Neuronal|

* Pyramidal
* Purkinje
* Granule
* Spindle
* Interneuron

|

Glial|

| insulating:|

* Myelination: Oligodendrocyte

|

other|

* Astrocyte
* Ependymal cells
* Tanycyte
* Microglia

PNS|

| General|

* Dorsal
* Root
* Ganglion
* Ramus
* Ventral
* Root
* Ramus
* Ramus communicans
* Gray
* White
* Autonomic ganglion (Preganglionic nerve fibers
* Postganglionic nerve fibers)
* Nerve fascicle
* Funiculus

|

Connective tissues|

* Epineurium
* Perineurium
* Endoneurium

Neuroglia|

* Myelination: Schwann cell
* Neurilemma
* Myelin incisure
* Node of Ranvier
* Internodal segment
* Satellite glial cell

Neurons/
nerve fibers|

| Parts|

| Soma|

* Axon hillock

|

Axon|

* Telodendron
* Axon terminals
* Axoplasm
* Axolemma
* Neurofibril/neurofilament

Dendrite|

*     * Nissl body
* Dendritic spine
* Apical dendrite/Basal dendrite

Types|

* Bipolar
* Unipolar
* Pseudounipolar
* Multipolar
* Interneuron
* Renshaw

Afferent nerve fiber/
Sensory neuron|

* GSA
* GVA
* SSA
* SVA
* fibers
* Ia or Aα
* Ib or Golgi or Aα
* II or Aβ and Aγ
* III or Aδ or fast pain
* IV or C or slow pain

Efferent nerve fiber/
Motor neuron|

* GSE
* GVE
* SVE
* Upper motor neuron
* Lower motor neuron
* α motorneuron
* β motorneuron
* γ motorneuron

Termination|

| Synapse|

* Electrical synapse/Gap junction
* Chemical synapse
* Synaptic vesicle
* Active zone
* Postsynaptic density
* Autapse
* Ribbon synapse
* Neuromuscular junction

|

Sensory receptors|

* Meissner's corpuscle
* Merkel nerve ending
* Pacinian corpuscle
* Ruffini ending
* Muscle spindle
* Free nerve ending
* Nociceptor
* Olfactory receptor neuron
* Photoreceptor cell
* Hair cell
* Taste bud

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