Zinc gluconate

Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Rabin Bista, M.B.B.S. [2]

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## Overview

Zinc gluconate is a lozenge that is FDA approved for the treatment of common cold. It reduces the severity of cold symptoms. Common adverse reactions include stomach upset.

## Adult Indications and Dosage

### FDA-Labeled Indications and Dosage (Adult)

#### Indications

* to reduce the duration of the common cold
* reduces the severity of cold symptoms: cough, sore throat, stuffy nose, sneezing, post nasal drip and/or hoarseness

#### DIRECTIONS

* adults and children 12 years and over
* for best results, begin treatment at start of symptoms (within 24-48 hours of onset)
* repeat every 2 - 4 hours as needed until all symptoms subside
* completely dissolve a COLD-EEZE® lozenge in mouth (do not chew)
* recommended daily dosage is 6 lozenges for adults and 4 lozenges for ages 12-17
* children under 12 years of age should consult a health professional prior to use

### Off-Label Use and Dosage (Adult)

#### Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Zinc gluconate in adult patients.

#### Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Zinc gluconate in adult patients.

## Pediatric Indications and Dosage

### FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Zinc gluconate in pediatric patients.

### Off-Label Use and Dosage (Pediatric)

#### Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Zinc gluconate in pediatric patients.

#### Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Zinc gluconate in pediatric patients.

## Contraindications

There is limited information regarding Zinc gluconate Contraindications in the drug label.

## Warnings

* Ask a doctor before use if you

* are taking minocycline, doxycycline, tetracycline or are on coumadin therapy,

zinc treatment may inhibit the absorption of these medicines

* Stop use and ask your healthcare practitioner if symptoms persist beyond 7 days.

* COLD-EEZE® Lozenges are formulated to reduce the duration of common cold symptoms and may be insufficient treatment for Influenza or Allergies.

* Diabetic Warning: sugar replacements may affect blood sugar levels.

* If pregnant or breast-feeding, ask a health professional before use.

* Keep out of reach of children.

## Adverse Reactions

### Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Zinc gluconate in the drug label.

### Postmarketing Experience

There is limited information regarding Postmarketing Experience of Zinc gluconate in the drug label.

## Drug Interactions

* Ask a doctor before use if you

* are taking minocycline, doxycycline, tetracycline or are on coumadin therapy,
* zinc treatment may inhibit the absorption of these medicines

## Use in Specific Populations

#### Pregnancy

Pregnancy Category (FDA):

* Pregnancy Category

Pregnancy Category (AUS):

* Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Zinc gluconate in women who are pregnant.

#### Labor and Delivery

There is no FDA guidance on use of Zinc gluconate during labor and delivery.

#### Nursing Mothers

There is no FDA guidance on the use of Zinc gluconate with respect to nursing mothers.

#### Pediatric Use

There is no FDA guidance on the use of Zinc gluconate with respect to pediatric patients.

#### Geriatic Use

There is no FDA guidance on the use of Zinc gluconate with respect to geriatric patients.

#### Gender

There is no FDA guidance on the use of Zinc gluconate with respect to specific gender populations.

#### Race

There is no FDA guidance on the use of Zinc gluconate with respect to specific racial populations.

#### Renal Impairment

There is no FDA guidance on the use of Zinc gluconate in patients with renal impairment.

#### Hepatic Impairment

There is no FDA guidance on the use of Zinc gluconate in patients with hepatic impairment.

#### Females of Reproductive Potential and Males

There is no FDA guidance on the use of Zinc gluconate in women of reproductive potentials and males.

#### Immunocompromised Patients

There is no FDA guidance one the use of Zinc gluconate in patients who are immunocompromised.

## Administration and Monitoring

#### Administration

* Oral

* completely dissolve a COLD-EEZE® lozenge in mouth (do not chew)

#### Monitoring

There is limited information regarding Monitoring of Zinc gluconate in the drug label.

* Description

## IV Compatibility

There is limited information regarding IV Compatibility of Zinc gluconate in the drug label.

## Overdosage

There is limited information regarding Overdose of Zinc gluconate in the drug label.

## Pharmacology

This image is taken from WikiPedia

### Mechanism of Action

### Structure

### Pharmacodynamics

There is limited information regarding Pharmacodynamics of Zinc gluconate in the drug label.

### Pharmacokinetics

There is limited information regarding Pharmacokinetics of Zinc gluconate in the drug label.

### Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Zinc gluconate in the drug label.

## Clinical Studies

There is limited information regarding Clinical Studies of Zinc gluconate in the drug label.

## How Supplied

There is limited information regarding Zinc gluconate How Supplied in the drug label.

### Storage

* store in a cool dry place after opening

## Images

### Drug Images

### Package and Label Display Panel

##### PRINCIPAL DISPLAY PANEL - 18 LOZENGE WILD CHERRY CARTON

GREAT NEW TASTE

Cold-EEZE® Zinc Gluconate Glycine

COLD REMEDY

SUGAR FREE

OTC Master's Circle Achievement Award

1. 1

Pharmacist Recommended Brand! Pharmacy Times

Clinically proven to reduce the duration of the common cold ®

1. 1 Pharmacist Recommended

Shortens your cold, works fast 18 Cold Remedy Lozenges

Homeopathic

All Natural Wild Cherry Flavor with other natural flavors

##### PRINCIPAL DISPLAY PANEL - 24 LOZENGE WILD CHERRY CARTON

GREAT NEW TASTE

Cold-EEZE® Zinc Gluconate Glycine

33% MORE FREE

COLD REMEDY

SUGAR FREE

OTC Master's Circle Achievement Award

1. 1

Pharmacist Recommended Brand! Pharmacy Times

Clinically proven to reduce the duration of the common cold ®

1. 1 Pharmacist Recommended

Shortens your cold, works fast 24 Cold Remedy Lozenges

Homeopathic

All Natural Wild Cherry Flavor with other natural flavors

##### Ingredients and Appearance

## Patient Counseling Information

* avoid minor stomach upset - Do not dissolve COLD-EEZE® lozenges on an empty stomach
* avoid citrus fruits or juices and products containing citric acid 1/2 hour before or after taking COLD-EEZE® lozenges as they may diminish product effectiveness, otherwise, drink plenty of fluids
* store in a cool dry place after opening
* gluten-free
* product may produce a laxative effect

## Precautions with Alcohol

* Alcohol-Zinc gluconate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

## Brand Names

* Cold-EEZE®[1]

## Look-Alike Drug Names

There is limited information regarding Zinc gluconate Look-Alike Drug Names in the drug label.

## Drug Shortage Status

## Price

## References

The contents of this FDA label are provided by the National Library of Medicine.

1. ↑ "Zinc gluconate".