5-(carboxyamino)imidazole ribonucleotide synthase

Class of enzymes

5-(Carboxyamino)imidazole ribonucleotide synthase

Identifiers
EC no.| 6.3.4.18
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) is an enzyme that catalyzes the chemical reaction

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3− ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

The 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole ("AIR"), and HCO3−, whereas its 3 products are ADP, phosphate, and 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming).

## References

[edit]

* Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM (1992). "Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway". Biochemistry. 31 (21): 5022–32\. doi:10.1021/bi00136a016. PMID 1534690.
* Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J (1994). "N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli". Biochemistry. 33 (8): 2269–78\. doi:10.1021/bi00174a038. PMID 8117684.
* Thoden JB, Kappock TJ, Stubbe J, Holden HM (1999). "Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily". Biochemistry. 38 (47): 15480–92\. doi:10.1021/bi991618s. PMID 10569930.

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Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen|

* Aminoacyl tRNA synthetase
* Alanine
* Arginine
* Asparagine
* Aspartate
* Cysteine
* D-Alanine—poly(phosphoribitol) ligase
* Glutamate
* Glutamine
* Glycine
* Histidine
* Isoleucine
* Leucine
* Lysine
* Methionine
* Phenylalanine
* Proline
* Serine
* Threonine
* Tryptophan
* Tyrosine
* Valine

6.2: Carbon-Sulfur|

* (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
* 2-furoate—CoA ligase
* 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase
* 3-hydroxybenzoate—CoA ligase
* 3-hydroxypropionyl-CoA synthase
* 4-chlorobenzoate—CoA ligase
* 4-Coumarate-CoA ligase
* 4-hydroxybenzoate—CoA ligase
* 6-carboxyhexanoate—CoA ligase
* Acetate—ACP ligase
* Acetate—CoA ligase (ADP-forming)
* Acetoacetate—CoA ligase
* Acetyl—CoA synthetase
* Acid—CoA ligase (GDP-forming)
* Anthranilate—CoA ligase
* Arachidonate—CoA ligase
* Benzoate—CoA ligase
* Biotin—CoA ligase
* (butirosin acyl-carrier protein)—L-glutamate ligase
* Butyrate—CoA ligase
* Cholate—CoA ligase
* Citrate—CoA ligase
* (citrate (pro-3S)-lyase) ligase
* Dicarboxylate—CoA ligase
* Glutarate—CoA ligase
* Long-chain-fatty-acid—ACP ligase
* Long-chain-fatty-acid—CoA ligase
* Malate—CoA ligase
* Malonate—CoA ligase
* o-Succinylbenzoate—CoA ligase
* Oxalate—CoA ligase
* Phenylacetate—CoA ligase
* Phytanate—CoA ligase
* Propionate—CoA ligase
* Succinate—CoA ligase (ADP-forming)
* Succinate—CoA ligase (GDP-forming)
* Succinyl—CoA synthetase
* trans-Feruloyl—CoA synthase

6.3: Carbon-Nitrogen|

* Glutamine synthetase
* Ubiquitin ligase
* Cullin
* Von Hippel–Lindau tumor suppressor
* UBE3A
* Mdm2
* Anaphase-promoting complex
* UBR1
* Glutathione synthetase
* CTP synthetase
* Adenylosuccinate synthase
* Argininosuccinate synthase
* Holocarboxylase synthetase
* GMP synthase
* Asparagine synthetase
* Carbamoyl phosphate synthetase
* I
* II
* Glutamate–cysteine ligase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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