AACS (gene)

AACS

Identifiers
Aliases| AACS, ACSF1, SUR-5, acetoacetyl-CoA synthetase
External IDs| OMIM: 614364; MGI: 1926144; HomoloGene: 11322; GeneCards: AACS; OMA:AACS - orthologs
| Gene location (Human)

Chr.| Chromosome 12 (human)[1]

Band| 12q24.31| Start| 125,065,434 bp[1]
End| 125,143,333 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 G1.1| Start| 125,552,878 bp[2]
End| 125,594,474 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* parotid gland

* gingival epithelium

* skin of arm

* nipple

* middle temporal gyrus

* vulva

* trachea

* tibia

* human penis

* skin of thigh

| Top expressed in

* right kidney

* tunica adventitia of aorta

* granulocyte

* proximal tubule

* lumbar spinal ganglion

* lip

* brown adipose tissue

* trachea

* white adipose tissue

* morula

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* nucleotide binding
* butyrate-CoA ligase activity
* ligase activity
* protein binding
* catalytic activity
* ATP binding
* acetoacetate-CoA ligase activity

Cellular component|

* cytoplasm
* cytosol

Biological process|

* response to organic cyclic compound
* response to nutrient
* lipid metabolism
* cellular response to testosterone stimulus
* cellular response to cholesterol
* fatty acid metabolic process
* response to purine-containing compound
* ketone body biosynthetic process
* response to organonitrogen compound
* response to starvation
* white fat cell differentiation
* liver development
* adipose tissue development
* metabolism
* response to ethanol
* cellular response to glucose stimulus
* response to oleic acid
* positive regulation of insulin secretion

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

65985

78894

Ensembl| |

ENSG00000081760

ENSMUSG00000029482

UniProt| |

Q86V21

Q9D2R0

RefSeq (mRNA)| |

NM_023928
NM_001319839
NM_001319840

NM_030210

RefSeq (protein)| |

NP_001306768
NP_001306769
NP_076417

NP_084486

Location (UCSC)| Chr 12: 125.07 – 125.14 Mb| Chr 5: 125.55 – 125.59 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.

The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.[5] It is expressed in a wide range of human tissues.[6]

## Function

[edit]

The protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).[7]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081760 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029482 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.
6. ^ "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.
7. ^ Aguiló F, Camarero N, Relat J, Marrero PF, Haro D (March 2010). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma" (PDF). The Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. PMID 20102333. S2CID 1043396.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

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